Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

Research output: Contribution to journalJournal articleResearchpeer-review

P B Jeppesen, B Hartmann, J Thulesen, J Graff, J Lohmann, B S Hansen, F Tofteng, Steen Seier Poulsen, J L Madsen, J J Holst, P B Mortensen

Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.
Original languageEnglish
JournalGastroenterology
Volume120
Issue number4
Pages (from-to)806-815
Number of pages10
ISSN0016-5085
Publication statusPublished - Mar 2001

    Research areas

  • Adult, Body Composition, Body Weight, Creatinine, Female, Gastrointestinal Hormones, Gastrointestinal Transit, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Hormones, Humans, Injections, Subcutaneous, Intestinal Absorption, Intestines, Male, Middle Aged, Nutritional Status, Patient Compliance, Peptides, Short Bowel Syndrome

ID: 168197