Genome-wide population-based association study of extremely overweight young adults--the GOYA study

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Lavinia Paternoster, David M Evans, Ellen Aagaard Nohr, Claus Holst, Valerie Gaborieau, Paul Brennan, Anette Prior Gjesing, Niels Grarup, Daniel R Witte, Torben Jørgensen, Allan René Linneberg, Torsten Lauritzen, Anelli Sandbaek, Torben Hansen, Oluf Borbye Pedersen, Katherine S Elliott, John P Kemp, Beate St Pourcain, George McMahon, Diana Zelenika & 5 others Jörg Hager, Mark Lathrop, Nicholas J Timpson, George Davey Smith, Thorkild I A Sørensen

Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.
Original languageEnglish
Article numbere24303
JournalP L o S One
Issue number9
Publication statusPublished - 2011

ID: 48513645