Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

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Gudmar Thorleifsson, G Bragi Walters, Daniel F Gudbjartsson, Valgerdur Steinthorsdottir, Patrick Sulem, Anna Helgadottir, Unnur Styrkarsdottir, Solveig Gretarsdottir, Steinunn Thorlacius, Ingileif Jonsdottir, Thorbjorg Jonsdottir, Elinborg J Olafsdottir, Gudridur H Olafsdottir, Thorvaldur Jonsson, Frosti Jonsson, Knut Borch-Johnsen, Torben Hansen, Gitte Andersen, Torben Jørgensen, Torsten Lauritzen & 15 others Katja K Aben, André L M Verbeek, Nel Roeleveld, Ellen Kampman, Lisa R Yanek, Lewis C Becker, Laufey Tryggvadottir, Thorunn Rafnar, Diane M Becker, Jeffrey Gulcher, Lambertus A Kiemeney, Oluf Pedersen, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
Original languageEnglish
JournalNature Genetics
Volume41
Issue number1
Pages (from-to)18-24
Number of pages6
ISSN1061-4036
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Base Sequence; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Gene Expression Regulation; Genetic Predisposition to Disease; Genome, Human; Genome-Wide Association Study; Humans; Obesity; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Quantitative Trait, Heritable

ID: 10000812