Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

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Eveliina Jakkula, Virpi Leppä, Anna-Maija Sulonen, Teppo Varilo, Suvi Kallio, Anu Kemppinen, Shaun Purcell, Keijo Koivisto, Pentti Tienari, Marja-Liisa Sumelahti, Irina Elovaara, Tuula Pirttilä, Mauri Reunanen, Arpo Aromaa, Annette Bang Oturai, Helle Bach Søndergaard, Hanne Harbo Hansen, Inger-Lise Mero, Stacey B Gabriel, Daniel B Mirel & 9 others Stephen L Hauser, Ludwig Kappos, Chris Polman, Philip L De Jager, David A Hafler, Mark J Daly, Aarno Palotie, Janna Saarela, Leena Peltonen

Genetic risk for multiple sclerosis (MS) is thought to involve both common and rare risk alleles. Recent GWAS and subsequent meta-analysis have established the critical role of the HLA locus and identified new common variants associated to MS. These variants have small odds ratios (ORs) and explain only a fraction of the genetic risk. To expose potentially rare, high-impact alleles, we conducted a GWAS of 68 distantly related cases and 136 controls from a high-risk internal isolate of Finland with increased prevalence and familial occurrence of MS. The top 27 loci with p <10(-4) were tested in 711 cases and 1029 controls from Finland, and the top two findings were validated in 3859 cases and 9110 controls from more heterogeneous populations. SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91). The protective haplotype for MS in STAT3 is a risk allele for Crohn disease, implying that STAT3 represents a shared risk locus for at least two autoimmune diseases. This study also demonstrates the potential of special isolated populations in search for variants contributing to complex traits.
Original languageEnglish
JournalAmerican Journal of Human Genetics
Volume86
Issue number2
Pages (from-to)285-91
Number of pages7
ISSN0002-9297
DOIs
Publication statusPublished - 12 Feb 2010

ID: 34152373