Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

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Alexander Teumer, Layal Chaker, Stefan Groeneweg, Yong Li, Celia Di Munno, Caterina Barbieri, Tarunveer S Ahluwalia, Arne Astrup, Allan Linneberg, Oluf Borbye Pedersen, Thorkild I.A. Sørensen, ThyroidOmics Consortium

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated
with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves’ disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.
Original languageEnglish
Article number4455
JournalNature Communications
Volume9
Number of pages14
ISSN2041-1723
DOIs
Publication statusPublished - 2018

    Research areas

  • The Faculty of Science - Thyroid dysfunction, Thyroid hormone regulation, Genome-wide analysis, Genetic variants, Thyroid hormone transporter (SLC17A4), Metabolyzing hormone (AADAT)

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