Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children
Research output: Contribution to journal › Journal article › Research › peer-review
Mette Hollensted, Mette Fogh, Theresia M Schnurr, Julie T Kloppenborg, Christian T Have, Tenna Ruest Haarmark Nielsen, Johanne Rask, Morten Asp Vonsild Lund, Christine Frithioff-Bøjsøe, Mia Østergaard Johansen, Emil Vincent Rosenbaum Appel, Yuvaraj Mahendran, Niels Grarup, Haja N Kadarmideen, Oluf Pedersen, Jens-Christian Holm, Torben Hansen
OBJECTIVE: This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents.
METHODS: Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models.
RESULTS: At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention.
CONCLUSIONS: A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.
|Number of pages||8|
|Publication status||Published - 2018|