Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians
Research output: Contribution to journal › Journal article › Research › peer-review
Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
|Journal||Clinical and Experimental Allergy|
|Number of pages||8|
|Publication status||Published - 1 Jan 2010|
- Acetaldehyde, Adolescent, Adult, Aged, Alcoholic Beverages, Alcoholism, Aldehyde Dehydrogenase, Alleles, Denmark, Drug Hypersensitivity, Ethanol, European Continental Ancestry Group, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged