Genetic burden of MS risk variants distinguish patients from healthy individuals but are not associated with disease activity

Research output: Contribution to journalJournal articleResearchpeer-review

Helle Bach Søndergaard, Eva Rosa Petersen, Melinda Magyari, Finn Sellebjerg, Annette Bang Oturai

Weighted genetic risk score (wGRS) was analysed for association with disease activity in more than 500 MS patients before and during interferon-beta treatment. The wGRS was higher in MS patients than in healthy controls when analysing eight HLA - and 109 non-HLA MS risk gene variants. No significant associations were observed between number of relapses prior to or during treatment with interferon-beta, both with and without HLA risk alleles included in the wGRS. In conclusion, among Danes the wGRS was higher in MS patients than controls but was not associated with the overall disease activity or response to treatment with interferon-beta.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Pages (from-to)25-27
Publication statusPublished - 2017

    Research areas

  • Adult, Alleles, Female, Genetic Predisposition to Disease, HLA Antigens/genetics, Humans, Interferon-beta/therapeutic use, Male, Multiple Sclerosis/drug therapy, Polymorphism, Single Nucleotide, Risk Factors

ID: 194769466