Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

L H Larsen, C S Rose, T Sparsø, J Overgaard, Signe Sørensen Torekov, N Grarup, D P Jensen, Anders Albrechtsen, G Andersen, J Ek, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
Original languageEnglish
JournalInternational Journal of Obesity
Volume31
Issue number2
Pages (from-to)365-70
Number of pages6
ISSN0307-0565
DOIs
Publication statusPublished - 2007

    Research areas

  • Aged, Anthropometry, Blood Glucose, Body Constitution, Chromosomes, Human, Pair 11, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Estrogen Receptor alpha, Female, Genetic Predisposition to Disease, Heat-Shock Proteins, Humans, Insulin, Linkage Disequilibrium, Lipids, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Transcription Factors

ID: 40246606