Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

Research output: Contribution to journalJournal articleResearchpeer-review

Carlota Pires, Benjamin Schmid, Carina Petræus, Anna Fong-Yee Poon, Natakarn Nimsanor, Troels Tolstrup Nielsen, Gunhild Waldemar, Lena Elisabeth Hjermind, Jørgen Erik Nielsen, Poul Hyttel, Kristine Freude

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation.

Original languageEnglish
JournalStem Cell Research
Volume17
Issue number2
Pages (from-to)285-288
Number of pages4
ISSN1873-5061
DOIs
Publication statusPublished - Sep 2016

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 173288754