Evidence of Extrapancreatic Glucagon Secretion in Man

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Asger Lund, Jonatan I Bagger, Nicolai J Wewer Albrechtsen, Mikkel Christensen, Magnus Grøndahl, Bolette Hartmann, Elisabeth R Mathiesen, Carsten P Hansen, Jan H Storkholm, Gerrit van Hall, Jens F Rehfeld, Daniel Hornburg, Felix Meissner, Matthias Mann, Steen Larsen, Jens J Holst, Tina Vilsbøll Lauritsen, Filip K Knop

Glucagon is believed to be a pancreas-specific hormone and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from alpha cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia represents a gut-dependent phenomenon and subjected 10 totally pancreatectomized patients and 10 healthy controls to a 75g-oral glucose tolerance test and a corresponding isoglycemic intravenous glucose infusion. We applied novel analytical methods of plasma glucagon (sandwich enzyme-linked immunosorbent assay and mass-spectrometry-based proteomics) and show that 29-amino acid glucagon circulates in patients without a pancreas and that glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients. These findings emphasize the existence of extrapancreatic glucagon (perhaps originating from the gut) in man and suggest that it may play a role in diabetes secondary to total pancreatectomy.

Original languageEnglish
JournalDiabetes
Volume65
Issue number3
Pages (from-to)585-597
Number of pages13
ISSN0012-1797
DOIs
Publication statusPublished - Mar 2016

Bibliographical note

Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585–597

ID: 152242782