Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes

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Signe S Torekov, Lesli H Larsen, Charlotte Glümer, Knut Borch-Johnsen, Torben Jørgensen, Jens J Holst, Ole D Madsen, Torben Hansen, Oluf Pedersen

We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25
Original languageEnglish
Issue number7
Pages (from-to)2261-5
Number of pages5
Publication statusPublished - 2005

    Research areas

  • Arginine, Body Mass Index, DNA, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Female, Humans, Male, Obesity, Odds Ratio, Pedigree, Peptide YY, Polymorphism, Genetic, Risk Factors, Sequence Deletion

ID: 38455799