Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?
Research output: Contribution to journal › Journal article › Research › peer-review
A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to high-level resistance, this highlights how transiently tolerant cells can develop resistance in response to antibiotic treatment.
|Journal||Trends in Microbiology|
|Publication status||Published - 2019|