Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes
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M Lodefalk, C Carlsson-Skwirut, Jens Juul Holst, J Aman, P. Bang
Aims: To compare the responses of GIP, GLP-1, ghrelin and IGFBP-1 between meals with different fat and energy content in adolescents with type 1 diabetes (T1DM) and to relate them to gastric emptying and glycaemia. Methods: On different days and in a random order, 7 adolescents with T1DM ingested a high- and low-fat meal (fat content: 38 and 2 g, energy content: 640 and 320 kcal, respectively). At normoglycaemia, the same prandial insulin dose was given at both meals and to all subjects. Postprandial blood samples were taken repeatedly over 4 hours. Gastric emptying was estimated by the paracetamol absorption method. Results: The area under the curve (AUC) for GIP(0-240 min) and for GLP-1(0-120 min) was larger, but smaller for relative ghrelin(0-240 min), after the high-fat meal (p = 0.002, 0.030 and 0.043, respectively). IGFBP-1 decreased significantly, but not differently, after the meals. Larger GLP-1 secretion correlated with slower gastric emptying (p = 0.029) and higher fasting ghrelin levels correlated with lower postprandial glycaemia (p = 0.007). Conclusion: In adolescents with T1DM, the postprandial responses of GIP, GLP-1 and ghrelin, but not that of IGFBP-1, depend more on meal size than on insulin.
|Journal||Hormone research in pædiatrics|
|Number of pages||8|
|Publication status||Published - 1 Jan 2010|
- Adolescent, Area Under Curve, Blood Glucose, Diabetes Mellitus, Type 1, Dietary Fats, Energy Intake, Female, Gastric Emptying, Gastric Inhibitory Polypeptide, Ghrelin, Glucagon-Like Peptide 1, Humans, Insulin, Insulin-Like Growth Factor Binding Protein 1, Male, Pilot Projects, Postprandial Period