Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

L.S. Mortensen, Jens Holmer-Jensen, Merete Hartvigsen, V.K. Jensen, Arne Astrup, M. de Vrese, Jens Juul Holst, Claus Heikki Paavo Thomsen, Kjeld Hermansen

Background/Objectives:Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects.Subjects/Methods:A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100¿g of butter and 45¿g of carbohydrate in combination with 45¿g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially.Results:We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period.Conclusions:A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.European Journal of Clinical Nutrition advance online publication, 16 May 2012; doi:10.1038/ejcn.2012.48.

Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number7
Pages (from-to)799-805
Number of pages7
ISSN0954-3007
DOIs
Publication statusPublished - 2012

    Research areas

  • Aged, Area Under Curve, Cardiovascular Diseases, Caseins, Chylomicrons, Diabetes Mellitus, Type 2, Dietary Fats, Dietary Proteins, Dietary Supplements, Female, Glycopeptides, Humans, Hyperlipidemias, Hypolipidemic Agents, Insulin, Lactalbumin, Male, Middle Aged, Milk Proteins, Postprandial Period, Protein Hydrolysates, Triglycerides, Vitamin A

ID: 38174120