Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

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Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. / Mortensen, L.S.; Holmer-Jensen, Jens; Hartvigsen, Merete; Jensen, V.K.; Astrup, Arne; Vrese, M. de; Holst, Jens Juul; Thomsen, Claus Heikki Paavo; Hermansen, Kjeld.

In: European Journal of Clinical Nutrition, Vol. 66, No. 7, 2012, p. 799-805.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Mortensen, LS, Holmer-Jensen, J, Hartvigsen, M, Jensen, VK, Astrup, A, Vrese, MD, Holst, JJ, Thomsen, CHP & Hermansen, K 2012, 'Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes', European Journal of Clinical Nutrition, vol. 66, no. 7, pp. 799-805. https://doi.org/10.1038/ejcn.2012.48

APA

Mortensen, L. S., Holmer-Jensen, J., Hartvigsen, M., Jensen, V. K., Astrup, A., Vrese, M. D., ... Hermansen, K. (2012). Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. European Journal of Clinical Nutrition, 66(7), 799-805. https://doi.org/10.1038/ejcn.2012.48

Vancouver

Mortensen LS, Holmer-Jensen J, Hartvigsen M, Jensen VK, Astrup A, Vrese MD et al. Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. European Journal of Clinical Nutrition. 2012;66(7):799-805. https://doi.org/10.1038/ejcn.2012.48

Author

Mortensen, L.S. ; Holmer-Jensen, Jens ; Hartvigsen, Merete ; Jensen, V.K. ; Astrup, Arne ; Vrese, M. de ; Holst, Jens Juul ; Thomsen, Claus Heikki Paavo ; Hermansen, Kjeld. / Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. In: European Journal of Clinical Nutrition. 2012 ; Vol. 66, No. 7. pp. 799-805.

Bibtex

@article{185a1d99d8004e5c8307e2e1882dfd78,
title = "Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes",
abstract = "Background/Objectives:Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects.Subjects/Methods:A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100¿g of butter and 45¿g of carbohydrate in combination with 45¿g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially.Results:We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period.Conclusions:A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.European Journal of Clinical Nutrition advance online publication, 16 May 2012; doi:10.1038/ejcn.2012.48.",
keywords = "Aged, Area Under Curve, Cardiovascular Diseases, Caseins, Chylomicrons, Diabetes Mellitus, Type 2, Dietary Fats, Dietary Proteins, Dietary Supplements, Female, Glycopeptides, Humans, Hyperlipidemias, Hypolipidemic Agents, Insulin, Lactalbumin, Male, Middle Aged, Milk Proteins, Postprandial Period, Protein Hydrolysates, Triglycerides, Vitamin A",
author = "L.S. Mortensen and Jens Holmer-Jensen and Merete Hartvigsen and V.K. Jensen and Arne Astrup and Vrese, {M. de} and Holst, {Jens Juul} and Thomsen, {Claus Heikki Paavo} and Kjeld Hermansen",
note = "IHE 2012 007",
year = "2012",
doi = "10.1038/ejcn.2012.48",
language = "English",
volume = "66",
pages = "799--805",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "nature publishing group",
number = "7",

}

RIS

TY - JOUR

T1 - Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

AU - Mortensen, L.S.

AU - Holmer-Jensen, Jens

AU - Hartvigsen, Merete

AU - Jensen, V.K.

AU - Astrup, Arne

AU - Vrese, M. de

AU - Holst, Jens Juul

AU - Thomsen, Claus Heikki Paavo

AU - Hermansen, Kjeld

N1 - IHE 2012 007

PY - 2012

Y1 - 2012

N2 - Background/Objectives:Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects.Subjects/Methods:A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100¿g of butter and 45¿g of carbohydrate in combination with 45¿g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially.Results:We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period.Conclusions:A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.European Journal of Clinical Nutrition advance online publication, 16 May 2012; doi:10.1038/ejcn.2012.48.

AB - Background/Objectives:Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects.Subjects/Methods:A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100¿g of butter and 45¿g of carbohydrate in combination with 45¿g of whey isolate (iso-meal), whey hydrolysate (hydro-meal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially.Results:We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso- and lac-meal in the chylomicron-rich fraction (P=0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro- and iso-meal produced a higher insulin response compared with the lac- and CGMP-meal (P<0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period.Conclusions:A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.European Journal of Clinical Nutrition advance online publication, 16 May 2012; doi:10.1038/ejcn.2012.48.

KW - Aged

KW - Area Under Curve

KW - Cardiovascular Diseases

KW - Caseins

KW - Chylomicrons

KW - Diabetes Mellitus, Type 2

KW - Dietary Fats

KW - Dietary Proteins

KW - Dietary Supplements

KW - Female

KW - Glycopeptides

KW - Humans

KW - Hyperlipidemias

KW - Hypolipidemic Agents

KW - Insulin

KW - Lactalbumin

KW - Male

KW - Middle Aged

KW - Milk Proteins

KW - Postprandial Period

KW - Protein Hydrolysates

KW - Triglycerides

KW - Vitamin A

U2 - 10.1038/ejcn.2012.48

DO - 10.1038/ejcn.2012.48

M3 - Journal article

VL - 66

SP - 799

EP - 805

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 7

ER -

ID: 38174120