Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Research output: Contribution to journalJournal articleResearchpeer-review

Signe Tellerup Nielsen, Louise Lehrskov-Schmidt, Rikke Krogh-Madsen, Thomas Solomon, Lars Lehrskov-Schmidt, Jens Juul Holst, Kirsten Møller

Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.
Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Online)
Volume29
Issue number8
Pages (from-to)655-663
Number of pages9
ISSN1520-7560
DOIs
Publication statusPublished - 31 Jul 2013

ID: 49898751