Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure

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Carsten Askov-Hansen, Palle B Jeppesen, Pernille Lund, Bolette Hartmann, Jens Juul Holst, Dennis B Henriksen

In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.
Original languageEnglish
JournalRegulatory Peptides
Volume181
Pages (from-to)4-8
Number of pages5
ISSN0167-0115
DOIs
Publication statusPublished - 10 Feb 2013

ID: 45840378