Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial

Research output: Contribution to journalJournal articleResearchpeer-review

Ulla Knorr, Maj Vinberg, Erik Lykke Mortensen, Per Winkel, Christian Gluud, Jørn Wetterslev, Ulrik Gether, Lars Vedel Kessing

The serotonergic neurotransmitter system is closely linked to depression and personality traits. It is not known if selective serotonin reuptake inhibitors (SSRI) have an effect on neuroticism that is independent of their effect on depression. Healthy individuals with a genetic liability for depression represent a group of particular interest when investigating if intervention with SSRIs affects personality. The present trial is the first to test the hypothesis that escitalopram may reduce neuroticism in healthy first-degree relatives of patients with major depressive disorder (MD).
Original languageEnglish
JournalP L o S One
Volume7
Issue number2
Pages (from-to)e31980
Number of pages7
ISSN1932-6203
DOIs
Publication statusPublished - 29 Feb 2012

ID: 38186391