Effect of bariatric surgery on plasma GDF15 in humans

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Maximilian Kleinert, Kirstine N Bojsen-Møller, Nils B Jørgensen, Maria S Svane, Christoffer Martinussen, Bente Kiens, Jørgen Wojtaszewski, Sten Madsbad, Erik Richter, Christoffer Clemmensen

Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycaemia in humans, we measured plasma GDF15 in patients with obesity (n = 25) and in patients with obesity and diabetes (n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 week after RYGB compared with before surgery (689 ± 45 pg/ml vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 months (554 ± 37 pg/ml, P < 0.05), at 1 year (566 ± 37 pg/ml, P < 0.05) and at 2.5-4 years (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery (r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 years following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 years post-surgery (r = 0.21, p<0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.

Original languageEnglish
JournalAmerican Journal of Physiology: Endocrinology and Metabolism
Volume316
Issue number4
Pages (from-to)E615-E621
Number of pages7
ISSN0193-1849
DOIs
Publication statusPublished - 2019

ID: 213153272