Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients

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Standard

Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients. / Ghotbi, Adam Ali; Hasbak, Philip; Nepper-Christensen, Lars; Lønborg, Jacob; Atharovski, Kiril; Christensen, Thomas; Holmvang, Lene; Engstrøm, Thomas; Ripa, Rasmus Sejersten; Kjær, Andreas.

In: Journal of Nuclear Cardiology, 2019, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ghotbi, AA, Hasbak, P, Nepper-Christensen, L, Lønborg, J, Atharovski, K, Christensen, T, Holmvang, L, Engstrøm, T, Ripa, RS & Kjær, A 2019, 'Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients', Journal of Nuclear Cardiology, pp. 1-12. https://doi.org/10.1007/s12350-017-0993-x

APA

Ghotbi, A. A., Hasbak, P., Nepper-Christensen, L., Lønborg, J., Atharovski, K., Christensen, T., ... Kjær, A. (2019). Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients. Journal of Nuclear Cardiology, 1-12. https://doi.org/10.1007/s12350-017-0993-x

Vancouver

Ghotbi AA, Hasbak P, Nepper-Christensen L, Lønborg J, Atharovski K, Christensen T et al. Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients. Journal of Nuclear Cardiology. 2019;1-12. https://doi.org/10.1007/s12350-017-0993-x

Author

Ghotbi, Adam Ali ; Hasbak, Philip ; Nepper-Christensen, Lars ; Lønborg, Jacob ; Atharovski, Kiril ; Christensen, Thomas ; Holmvang, Lene ; Engstrøm, Thomas ; Ripa, Rasmus Sejersten ; Kjær, Andreas. / Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients. In: Journal of Nuclear Cardiology. 2019 ; pp. 1-12.

Bibtex

@article{98e485536b064f90b8df1f521c7535e1,
title = "Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients",
abstract = "BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R (2) = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R (2) = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.CONCLUSIONS: Subacute rest-only (82)Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.",
keywords = "Journal Article",
author = "Ghotbi, {Adam Ali} and Philip Hasbak and Lars Nepper-Christensen and Jacob L{\o}nborg and Kiril Atharovski and Thomas Christensen and Lene Holmvang and Thomas Engstr{\o}m and Ripa, {Rasmus Sejersten} and Andreas Kj{\ae}r",
year = "2019",
doi = "10.1007/s12350-017-0993-x",
language = "English",
pages = "1--12",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients

AU - Ghotbi, Adam Ali

AU - Hasbak, Philip

AU - Nepper-Christensen, Lars

AU - Lønborg, Jacob

AU - Atharovski, Kiril

AU - Christensen, Thomas

AU - Holmvang, Lene

AU - Engstrøm, Thomas

AU - Ripa, Rasmus Sejersten

AU - Kjær, Andreas

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R (2) = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R (2) = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.CONCLUSIONS: Subacute rest-only (82)Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.

AB - BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R (2) = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R (2) = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.CONCLUSIONS: Subacute rest-only (82)Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85024501160&partnerID=8YFLogxK

U2 - 10.1007/s12350-017-0993-x

DO - 10.1007/s12350-017-0993-x

M3 - Journal article

SP - 1

EP - 12

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -

ID: 184290529