Early goal-directed nutrition in icU patients (EAT-ICU): protocol for a randomised trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Early goal-directed nutrition in icU patients (EAT-ICU) : protocol for a randomised trial. / Allingstrup, Matilde Jo; Kondrup, Jens; Wiis, Jørgen; Claudius, Casper; Pedersen, Ulf Gøttrup; Hein-Rasmussen, Rikke; Jensen, Tom Hartvig; Lange, Theis; Perner, Anders.

In: Danish Medical Journal, Vol. 63, No. 9, A5271, 09.2016, p. 1-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Allingstrup, MJ, Kondrup, J, Wiis, J, Claudius, C, Pedersen, UG, Hein-Rasmussen, R, Jensen, TH, Lange, T & Perner, A 2016, 'Early goal-directed nutrition in icU patients (EAT-ICU): protocol for a randomised trial', Danish Medical Journal, vol. 63, no. 9, A5271, pp. 1-6.

APA

Allingstrup, M. J., Kondrup, J., Wiis, J., Claudius, C., Pedersen, U. G., Hein-Rasmussen, R., ... Perner, A. (2016). Early goal-directed nutrition in icU patients (EAT-ICU): protocol for a randomised trial. Danish Medical Journal, 63(9), 1-6. [A5271].

Vancouver

Allingstrup MJ, Kondrup J, Wiis J, Claudius C, Pedersen UG, Hein-Rasmussen R et al. Early goal-directed nutrition in icU patients (EAT-ICU): protocol for a randomised trial. Danish Medical Journal. 2016 Sep;63(9):1-6. A5271.

Author

Allingstrup, Matilde Jo ; Kondrup, Jens ; Wiis, Jørgen ; Claudius, Casper ; Pedersen, Ulf Gøttrup ; Hein-Rasmussen, Rikke ; Jensen, Tom Hartvig ; Lange, Theis ; Perner, Anders. / Early goal-directed nutrition in icU patients (EAT-ICU) : protocol for a randomised trial. In: Danish Medical Journal. 2016 ; Vol. 63, No. 9. pp. 1-6.

Bibtex

@article{ee7b3838ebdc4a12bf7e85ebf128cdf7,
title = "Early goal-directed nutrition in icU patients (EAT-ICU): protocol for a randomised trial",
abstract = "INTRODUCTION: Extensive weight loss has been docu-mented in intensive care unit (ICU) survivors, primarily as the result of muscle loss, leading to impaired physical function and reduced quality of life. The aim of the EAT-ICU trial is to test the effect of early goal-directed protein-energy nutrition based on measured requirements on short-term clinical outcomes and long-term physical quality of life in ICU patients.METHODS: The EAT-ICU trial is a single-centre, randomised, parallel-group trial with concealed allocation and blinded outcome assessment. A total of 200 consecutive, acutely admitted, mechanically ventilated intensive care patients will be randomised 1:1 to early goal-directed nutrition versus standard of care to show a potential 15{\%} relative risk reduction in the primary outcome measure (physical function) at six months (two-sided significance level α = 0.05; power β = 80{\%}). Secondary outcomes include energy- and protein balances, metabolic control, new organ failure, use of life support, nosocomial infections, ICU- and hospital length of stay, mortality and cost analyses.CONCLUSION: The optimal nutrition strategy for ICU patients remains unsettled. The EAT-ICU trial will provide important data on the effects of early goal-directed protein-energy nutrition based on measured requirements in these patients.FUNDING: The EAT-ICU trial is funded by Copenhagen University Hospital, Rigshospitalet and Fresenius Kabi A/S and supported by The European Society for Clinical Nutrition and Metabolism (ESPEN).TRIAL REGISTRATION: Clinicaltrials.gov identifier no. NCT01372176.",
keywords = "Journal Article",
author = "Allingstrup, {Matilde Jo} and Jens Kondrup and J{\o}rgen Wiis and Casper Claudius and Pedersen, {Ulf G{\o}ttrup} and Rikke Hein-Rasmussen and Jensen, {Tom Hartvig} and Theis Lange and Anders Perner",
year = "2016",
month = "9",
language = "English",
volume = "63",
pages = "1--6",
journal = "Danish Medical Journal",
issn = "1603-9629",
publisher = "Almindelige Danske Laegeforening",
number = "9",

}

RIS

TY - JOUR

T1 - Early goal-directed nutrition in icU patients (EAT-ICU)

T2 - protocol for a randomised trial

AU - Allingstrup, Matilde Jo

AU - Kondrup, Jens

AU - Wiis, Jørgen

AU - Claudius, Casper

AU - Pedersen, Ulf Gøttrup

AU - Hein-Rasmussen, Rikke

AU - Jensen, Tom Hartvig

AU - Lange, Theis

AU - Perner, Anders

PY - 2016/9

Y1 - 2016/9

N2 - INTRODUCTION: Extensive weight loss has been docu-mented in intensive care unit (ICU) survivors, primarily as the result of muscle loss, leading to impaired physical function and reduced quality of life. The aim of the EAT-ICU trial is to test the effect of early goal-directed protein-energy nutrition based on measured requirements on short-term clinical outcomes and long-term physical quality of life in ICU patients.METHODS: The EAT-ICU trial is a single-centre, randomised, parallel-group trial with concealed allocation and blinded outcome assessment. A total of 200 consecutive, acutely admitted, mechanically ventilated intensive care patients will be randomised 1:1 to early goal-directed nutrition versus standard of care to show a potential 15% relative risk reduction in the primary outcome measure (physical function) at six months (two-sided significance level α = 0.05; power β = 80%). Secondary outcomes include energy- and protein balances, metabolic control, new organ failure, use of life support, nosocomial infections, ICU- and hospital length of stay, mortality and cost analyses.CONCLUSION: The optimal nutrition strategy for ICU patients remains unsettled. The EAT-ICU trial will provide important data on the effects of early goal-directed protein-energy nutrition based on measured requirements in these patients.FUNDING: The EAT-ICU trial is funded by Copenhagen University Hospital, Rigshospitalet and Fresenius Kabi A/S and supported by The European Society for Clinical Nutrition and Metabolism (ESPEN).TRIAL REGISTRATION: Clinicaltrials.gov identifier no. NCT01372176.

AB - INTRODUCTION: Extensive weight loss has been docu-mented in intensive care unit (ICU) survivors, primarily as the result of muscle loss, leading to impaired physical function and reduced quality of life. The aim of the EAT-ICU trial is to test the effect of early goal-directed protein-energy nutrition based on measured requirements on short-term clinical outcomes and long-term physical quality of life in ICU patients.METHODS: The EAT-ICU trial is a single-centre, randomised, parallel-group trial with concealed allocation and blinded outcome assessment. A total of 200 consecutive, acutely admitted, mechanically ventilated intensive care patients will be randomised 1:1 to early goal-directed nutrition versus standard of care to show a potential 15% relative risk reduction in the primary outcome measure (physical function) at six months (two-sided significance level α = 0.05; power β = 80%). Secondary outcomes include energy- and protein balances, metabolic control, new organ failure, use of life support, nosocomial infections, ICU- and hospital length of stay, mortality and cost analyses.CONCLUSION: The optimal nutrition strategy for ICU patients remains unsettled. The EAT-ICU trial will provide important data on the effects of early goal-directed protein-energy nutrition based on measured requirements in these patients.FUNDING: The EAT-ICU trial is funded by Copenhagen University Hospital, Rigshospitalet and Fresenius Kabi A/S and supported by The European Society for Clinical Nutrition and Metabolism (ESPEN).TRIAL REGISTRATION: Clinicaltrials.gov identifier no. NCT01372176.

KW - Journal Article

M3 - Journal article

VL - 63

SP - 1

EP - 6

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 1603-9629

IS - 9

M1 - A5271

ER -

ID: 165920959