Dissecting signaling and functions of adhesion G protein-coupled receptors

Research output: Contribution to journalJournal articleResearchpeer-review

Demet Araç, Gabriela Aust, Davide Calebiro, Felix B Engel, Caroline Formstone, André Goffinet, Jörg Hamann, Robert J Kittel, Ines Liebscher, Hsi-Hsien Lin, Kelly R Monk, Alexander Petrenko, Xianhua Piao, Simone Prömel, Helgi B Schiöth, Thue W. Schwartz, Martin Stacey, Yuri A Ushkaryov, Manja Wobus, Uwe Wolfrum & 2 others Lei Xu, Tobias Langenhan

G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.

Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Volume1276
Pages (from-to)1-25
Number of pages25
ISSN0077-8923
DOIs
Publication statusPublished - Dec 2012

    Research areas

  • Cell Adhesion, Humans, Ligands, Models, Biological, Proteolysis, Receptors, G-Protein-Coupled, Signal Transduction

ID: 137294388