Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

Research output: Contribution to journalJournal articleResearchpeer-review

T Edholm, M Degerblad, P Grybäck, L Hilsted, Jens Juul Holst, H Jacobsson, S Efendic, P T Schmidt, P M Hellström

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins with important effects on glucoregulatory functions. The aim of this study was to investigate effects of GIP and GLP-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans.
Original languageEnglish
JournalNeurogastroenterology and Motility Online
Volume22
Issue number11
Pages (from-to)1191-200, e315
Number of pages10
ISSN1365-2982
DOIs
Publication statusPublished - 1 Nov 2010

    Research areas

  • Adult, Appetite, Blood Glucose, C-Peptide, Cross-Over Studies, Double-Blind Method, Female, Gastric Emptying, Gastric Inhibitory Polypeptide, Ghrelin, Glucagon, Glucagon-Like Peptide 1, Homeostasis, Humans, Hunger, Immunoassay, Incretins, Insulin, Male, Peptide YY, Satiety Response

ID: 33939474