D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke

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Bodil Cathrine Koch, Luca Motta, Bo Wiinberg, Ulrik Westrup, Annemarie Thuri Kristensen, Geoff Skerritt, Mette Berendt, Hanne Gredal

Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke.
Original languageEnglish
Article number255
JournalFrontiers in Veterinary Science
Volume6
Number of pages7
ISSN2297-1769
DOIs
Publication statusPublished - 2019

    Research areas

  • ischemic stroke, infarction, cerebrovascular accident, hemostatic parameters, D-dimer, hypercoagulability, thromboelastography, TEG

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