Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

Research output: Contribution to journalJournal articleResearchpeer-review

Mikkel Andreassen, Henrik Vestergaard, Lars Østergaard Kristensen

Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.
Original languageEnglish
JournalClinical Endocrinology
Issue number6
Pages (from-to)909-16
Number of pages8
Publication statusPublished - Dec 2007

    Research areas

  • Acromegaly, Adipokines, Adolescent, Adult, C-Reactive Protein, Case-Control Studies, Dwarfism, Pituitary, Female, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Interleukin-6, Lectins, Male, Middle Aged, Young Adult

ID: 92190487