Concanavalin A-induced activation of lymphocytic choriomeningitis virus memory lymphocytes into specifically cytotoxic T cells

Research output: Contribution to journalJournal articleResearchpeer-review

O Marker, Allan Randrup Thomsen, G T Andersen

When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.
Original languageEnglish
JournalActa pathologica et microbiologica Scandinavica. Section C, Immunology
Issue number6
Pages (from-to)483-6
Number of pages3
Publication statusPublished - 1977

Bibliographical note

Keywords: Animals; Concanavalin A; Cytotoxicity, Immunologic; Immunologic Memory; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C3H; Spleen; T-Lymphocytes

ID: 9702595