Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

Research output: Contribution to journalJournal articleResearchpeer-review

Erling Mellerup, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Pernille Koefoed, Ingrid Melle, Ole Mors, Thomas Werge, Gert Lykke Moeller

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

Original languageEnglish
Article numbere0143432
JournalP L o S One
Volume10
Issue number11
Number of pages7
ISSN1932-6203
DOIs
Publication statusPublished - 2015

ID: 162068117