Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
Research output: Contribution to journal › Journal article › Research › peer-review
Erling Mellerup, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Pernille Koefoed, Ingrid Melle, Ole Mors, Thomas Werge, Gert Lykke Moeller
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
|Journal||P L o S One|
|Number of pages||7|
|Publication status||Published - 2015|