Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

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Lars Bo Nielsen, K.B. Ploug, P. Swift, Anne Cathrine Ørskov, I. Jansen-Olesen, F. Chiarelli, J.J. Holst, Poul Philip Hougaard, S. Porksen, R. Holl, C. de Beaufort, S. Gammeltoft, P. Rorsman, Henrik B. Mortensen, L. Hansen, Lotte B Nielsen, Kenneth B Ploug, Peter Swift, Cathrine Ørskov, Inger Jansen-Olesen & 11 others Francesco Chiarelli, Jens Juul Holst, Philip Hougaard, Sven Pörksen, Reinhard Holl, Carine de Beaufort, Steen Gammeltoft, Patrik Rorsman, Henrik B Mortensen, Lars Hansen, Hvidøre Study Group

The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume156
Issue number6
Pages (from-to)663-71
Number of pages9
ISSN0804-4643
DOIs
Publication statusPublished - 2007

ID: 4040309