Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

Research output: Contribution to journalJournal articleResearchpeer-review

Rong Jiang, Beverly H Brummett, Elizabeth R Hauser, Michael A Babyak, Ilene C Siegler, Abanish Singh, Arne Astrup, Oluf Pedersen, Torben Hansen, Claus Holst, Thorkild I A Sørensen, Redford B Williams

TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.
Original languageEnglish
JournalBiological Psychology
Volume93
Issue number1
Pages (from-to)184-189
Number of pages6
ISSN0301-0511
DOIs
Publication statusPublished - 2013

ID: 44853343