Chemogenomics of allosteric binding sites in GPCRs

Research output: Contribution to journalJournal articleResearchpeer-review

Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.
Original languageEnglish
JournalDrug Discovery Today: Technologies
Issue number2
Pages (from-to)e307-13
Publication statusPublished - 2013

ID: 94028199