Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. / Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

In: Current Pharmaceutical Design, Vol. 21, No. 19, 2015, p. 2611-28.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christophersen, PC, Fano, M, Saaby, L, Yang, M, Nielsen, HM & Mu, H 2015, 'Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs', Current Pharmaceutical Design, vol. 21, no. 19, pp. 2611-28. https://doi.org/10.2174/1381612821666150416100943

APA

Christophersen, P. C., Fano, M., Saaby, L., Yang, M., Nielsen, H. M., & Mu, H. (2015). Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. Current Pharmaceutical Design, 21(19), 2611-28. https://doi.org/10.2174/1381612821666150416100943

Vancouver

Christophersen PC, Fano M, Saaby L, Yang M, Nielsen HM, Mu H. Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. Current Pharmaceutical Design. 2015;21(19):2611-28. https://doi.org/10.2174/1381612821666150416100943

Author

Christophersen, Philip Carsten ; Fano, Mathias ; Saaby, Lasse ; Yang, Mingshi ; Nielsen, Hanne Mørck ; Mu, Huiling. / Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. In: Current Pharmaceutical Design. 2015 ; Vol. 21, No. 19. pp. 2611-28.

Bibtex

@article{3edcc1f49cfe488a8b94e55c69f7121f,
title = "Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs",
abstract = "Oral drug delivery is a preferred route because of good patient compliance. However, most peptide/ protein drugs are delivered via parenteral routes because of the absorption barriers in the gastrointestinal (GI) tract such as enzymatic degradation by proteases and low permeability acrossthe biological membranes. To overcome these barriers, different formulation strategies for oral delivery of biomacromolecules have been proposed, including lipid based formulations and polymer-based particulate drug delivery systems (DDS). The aim of this review is to summarize the existing knowledge about oral delivery of peptide/protein drugs and to provide an overview of formulationand characterization strategies. For a better understanding of the challenges in oral delivery of peptide/protein drugs, the composition of GI fluids and the digestion processes of different kinds of excipients in the GI tract are summarized. Additionally, the paper provides an overview of recent studies on characterization of solid drug carriers for peptide/protein drugs, drug distribution in particles, drug release and stability in simulated GI fluids, as well as the absorption of peptide/protein drugs in cell-based models. The use of biorelevant media when applicable can increase the knowledge about the quality of DDS for oral protein delivery. Hopefully, the knowledge provided in this review will aid the establishment of improved biorelevant models capable of forecasting the performance of particulate DDS for oral peptide/protein delivery.",
author = "Christophersen, {Philip Carsten} and Mathias Fano and Lasse Saaby and Mingshi Yang and Nielsen, {Hanne M{\o}rck} and Huiling Mu",
year = "2015",
doi = "10.2174/1381612821666150416100943",
language = "English",
volume = "21",
pages = "2611--28",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers",
number = "19",

}

RIS

TY - JOUR

T1 - Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs

AU - Christophersen, Philip Carsten

AU - Fano, Mathias

AU - Saaby, Lasse

AU - Yang, Mingshi

AU - Nielsen, Hanne Mørck

AU - Mu, Huiling

PY - 2015

Y1 - 2015

N2 - Oral drug delivery is a preferred route because of good patient compliance. However, most peptide/ protein drugs are delivered via parenteral routes because of the absorption barriers in the gastrointestinal (GI) tract such as enzymatic degradation by proteases and low permeability acrossthe biological membranes. To overcome these barriers, different formulation strategies for oral delivery of biomacromolecules have been proposed, including lipid based formulations and polymer-based particulate drug delivery systems (DDS). The aim of this review is to summarize the existing knowledge about oral delivery of peptide/protein drugs and to provide an overview of formulationand characterization strategies. For a better understanding of the challenges in oral delivery of peptide/protein drugs, the composition of GI fluids and the digestion processes of different kinds of excipients in the GI tract are summarized. Additionally, the paper provides an overview of recent studies on characterization of solid drug carriers for peptide/protein drugs, drug distribution in particles, drug release and stability in simulated GI fluids, as well as the absorption of peptide/protein drugs in cell-based models. The use of biorelevant media when applicable can increase the knowledge about the quality of DDS for oral protein delivery. Hopefully, the knowledge provided in this review will aid the establishment of improved biorelevant models capable of forecasting the performance of particulate DDS for oral peptide/protein delivery.

AB - Oral drug delivery is a preferred route because of good patient compliance. However, most peptide/ protein drugs are delivered via parenteral routes because of the absorption barriers in the gastrointestinal (GI) tract such as enzymatic degradation by proteases and low permeability acrossthe biological membranes. To overcome these barriers, different formulation strategies for oral delivery of biomacromolecules have been proposed, including lipid based formulations and polymer-based particulate drug delivery systems (DDS). The aim of this review is to summarize the existing knowledge about oral delivery of peptide/protein drugs and to provide an overview of formulationand characterization strategies. For a better understanding of the challenges in oral delivery of peptide/protein drugs, the composition of GI fluids and the digestion processes of different kinds of excipients in the GI tract are summarized. Additionally, the paper provides an overview of recent studies on characterization of solid drug carriers for peptide/protein drugs, drug distribution in particles, drug release and stability in simulated GI fluids, as well as the absorption of peptide/protein drugs in cell-based models. The use of biorelevant media when applicable can increase the knowledge about the quality of DDS for oral protein delivery. Hopefully, the knowledge provided in this review will aid the establishment of improved biorelevant models capable of forecasting the performance of particulate DDS for oral peptide/protein delivery.

U2 - 10.2174/1381612821666150416100943

DO - 10.2174/1381612821666150416100943

M3 - Journal article

VL - 21

SP - 2611

EP - 2628

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 19

ER -

ID: 141979000