Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

Research output: Contribution to journalJournal articleResearchpeer-review

Inger Hee Mabuza Mathiesen, Mohammad Salem, Jan Gerstoft, Julie Christine Gaardbo, Niels Obel, Court Pedersen, Henrik Ullum, Susanne Dam Nielsen, Ann-Brit Eg Hansen

BACKGROUND: By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery.

METHODS: We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation.

RESULTS: Soluble RANKL changed significantly over time (overall p = 0.02) with 25% decrease (95% CI: -42 to -5) at week 24 compared to baseline and stabilized at a lower level thereafter. We found no correlation between CD4+ T cell count increment and changes in sRANKL or between percentage change in BMD and changes in sRANKL.

CONCLUSION: In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART.

TRIAL REGISTRATION: Clinical-Trial.gov . id NCT00135460 , August 25, 2005. The study was approved by the Danish Data Protection Agency, Danish Medicines Agency and Regional Ethics Committee.

Original languageEnglish
Article number262
JournalB M C Infectious Diseases
Volume17
Number of pages7
ISSN1471-2334
DOIs
Publication statusPublished - 11 Apr 2017

    Research areas

  • Adult, Anti-HIV Agents, CD4-Positive T-Lymphocytes, Drug Therapy, Combination, Female, HIV Infections, Humans, Lymphocyte Count, Male, Middle Aged, RANK Ligand, Journal Article

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