Calcium ion activity in physiological salt solutions: influence of anions substituted for chloride

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Gert Rene Juul Christoffersen, Leif H Skibsted

1. Substitution by different anions for chloride in physiological salt solutions leads to binding between Ca2+ and the anion. Experiments designed to test effects of Cl- therefore often show mixed effects of changes in Cl- and Ca2+ activity.


2. This mixed effect is demonstrated in neurons of the snail, Helix pomatia: current-voltage characteristics and membrane potential are described during reduction of extracellular Cl- using different anions as substitutes. Methylsulphate is concluded to be the best substitute in this preparation.

3. The association constants for the binding of Ca2+ to a number of anions is given.

Original languageEnglish
JournalComparative Biochemistry and Physiology - Part A: Comparative Physiology
Issue number2
Pages (from-to)317-322
Number of pages6
Publication statusPublished - 1975

Bibliographical note

Key Word Index: Helix; nerve potentials; Calcium ions; methylsulphate; chloride

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