Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Research output: Contribution to journalJournal articleResearchpeer-review

Gregory W. Severin, Carsten H. Nielsen, Andreas I. Jensen, Jesper Fonslet, Andreas Kjær, Fedor Zhuravlev

We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

Original languageEnglish
JournalJournal of Medicinal Chemistry
Volume58
Issue number18
Pages (from-to)7591-7595
Number of pages5
ISSN0022-2623
DOIs
Publication statusPublished - 24 Sep 2015

ID: 147663189