Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Research output: Contribution to journalJournal articleResearchpeer-review

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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. / Kuhre, Rune Ehrenreich; Albrechtsen, Nicolai Jacob Wewer; Larsen, Olav; Jepsen, Sara Lind; Balk-Møller, Emilie; Andersen, Daniel Bjørklund; Deacon, Carolyn F.; Schoonjans, Kristina; Reimann, Frank ; Gribble, Fiona M.; Albrechtsen, Reidar; Hartmann, Bolette; Rosenkilde, Mette; Holst, Jens Juul.

In: Molecular Metabolism, Vol. 11, 2018, p. 84-95.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kuhre, RE, Albrechtsen, NJW, Larsen, O, Jepsen, SL, Balk-Møller, E, Andersen, DB, Deacon, CF, Schoonjans, K, Reimann, F, Gribble, FM, Albrechtsen, R, Hartmann, B, Rosenkilde, M & Holst, JJ 2018, 'Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.', Molecular Metabolism, vol. 11, pp. 84-95. https://doi.org/10.1016/j.molmet.2018.03.007

APA

Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., ... Holst, J. J. (2018). Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Molecular Metabolism, 11, 84-95. https://doi.org/10.1016/j.molmet.2018.03.007

Vancouver

Kuhre RE, Albrechtsen NJW, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB et al. Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Molecular Metabolism. 2018;11:84-95. https://doi.org/10.1016/j.molmet.2018.03.007

Author

Kuhre, Rune Ehrenreich ; Albrechtsen, Nicolai Jacob Wewer ; Larsen, Olav ; Jepsen, Sara Lind ; Balk-Møller, Emilie ; Andersen, Daniel Bjørklund ; Deacon, Carolyn F. ; Schoonjans, Kristina ; Reimann, Frank ; Gribble, Fiona M. ; Albrechtsen, Reidar ; Hartmann, Bolette ; Rosenkilde, Mette ; Holst, Jens Juul. / Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. In: Molecular Metabolism. 2018 ; Vol. 11. pp. 84-95.

Bibtex

@article{c3776646bf4e4caab8e2487a952caba4,
title = "Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.",
abstract = "OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated secretion of appetite and metabolism regulating hormones from the gut and pancreas is not well described and was the purpose of this study. METHODS: The effects of bile acids on the secretion of gut and pancreatic hormones was studied in rats and compared to the most well described nutritional secretagogue: glucose. The molecular mechanisms that underlie the secretion was studied by isolated perfused rat and mouse small intestine and pancreas preparations and supported by immunohistochemistry, expression analysis, and pharmacological studies. RESULTS: Bile acids robustly stimulate secretion of not only the incretin hormones, glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP-1), but also glucagon and insulin in vivo, to levels comparable to those resulting from glucose stimulation. The mechanisms of GLP-1, neurotensin, and peptide YY (PYY) secretion was secondary to intestinal absorption and depended on activation of basolateral membrane Takeda G-protein receptor 5 (TGR5) receptors on the L-cells in the following order of potency: Lithocholic acid (LCA) >Deoxycholicacid (DCA)>Chenodeoxycholicacid (CDCA)> Cholic acid (CA). Thus BAs did not stimulate secretion of GLP-1 and PYY from perfused small intestine in TGR5 KO mice but stimulated robust responses in wild type littermates. TGR5 is not expressed on α-cells or β-cells, and BAs had no direct effects on glucagon or insulin secretion from the perfused pancreas. CONCLUSION: BAs should be considered not only as fat emulsifiers but also as important regulators of appetite- and metabolism-regulating hormones by activation of basolateral intestinal TGR5.",
keywords = "Bile-acids, GLP-1, Insulin, Neurotensin, PYY, TGR5",
author = "Kuhre, {Rune Ehrenreich} and Albrechtsen, {Nicolai Jacob Wewer} and Olav Larsen and Jepsen, {Sara Lind} and Emilie Balk-M{\o}ller and Andersen, {Daniel Bj{\o}rklund} and Deacon, {Carolyn F.} and Kristina Schoonjans and Frank Reimann and Gribble, {Fiona M.} and Reidar Albrechtsen and Bolette Hartmann and Mette Rosenkilde and Holst, {Jens Juul}",
year = "2018",
doi = "10.1016/j.molmet.2018.03.007",
language = "English",
volume = "11",
pages = "84--95",
journal = "Molecular Metabolism",
issn = "2212-8778",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

AU - Kuhre, Rune Ehrenreich

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Larsen, Olav

AU - Jepsen, Sara Lind

AU - Balk-Møller, Emilie

AU - Andersen, Daniel Bjørklund

AU - Deacon, Carolyn F.

AU - Schoonjans, Kristina

AU - Reimann, Frank

AU - Gribble, Fiona M.

AU - Albrechtsen, Reidar

AU - Hartmann, Bolette

AU - Rosenkilde, Mette

AU - Holst, Jens Juul

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated secretion of appetite and metabolism regulating hormones from the gut and pancreas is not well described and was the purpose of this study. METHODS: The effects of bile acids on the secretion of gut and pancreatic hormones was studied in rats and compared to the most well described nutritional secretagogue: glucose. The molecular mechanisms that underlie the secretion was studied by isolated perfused rat and mouse small intestine and pancreas preparations and supported by immunohistochemistry, expression analysis, and pharmacological studies. RESULTS: Bile acids robustly stimulate secretion of not only the incretin hormones, glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP-1), but also glucagon and insulin in vivo, to levels comparable to those resulting from glucose stimulation. The mechanisms of GLP-1, neurotensin, and peptide YY (PYY) secretion was secondary to intestinal absorption and depended on activation of basolateral membrane Takeda G-protein receptor 5 (TGR5) receptors on the L-cells in the following order of potency: Lithocholic acid (LCA) >Deoxycholicacid (DCA)>Chenodeoxycholicacid (CDCA)> Cholic acid (CA). Thus BAs did not stimulate secretion of GLP-1 and PYY from perfused small intestine in TGR5 KO mice but stimulated robust responses in wild type littermates. TGR5 is not expressed on α-cells or β-cells, and BAs had no direct effects on glucagon or insulin secretion from the perfused pancreas. CONCLUSION: BAs should be considered not only as fat emulsifiers but also as important regulators of appetite- and metabolism-regulating hormones by activation of basolateral intestinal TGR5.

AB - OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated secretion of appetite and metabolism regulating hormones from the gut and pancreas is not well described and was the purpose of this study. METHODS: The effects of bile acids on the secretion of gut and pancreatic hormones was studied in rats and compared to the most well described nutritional secretagogue: glucose. The molecular mechanisms that underlie the secretion was studied by isolated perfused rat and mouse small intestine and pancreas preparations and supported by immunohistochemistry, expression analysis, and pharmacological studies. RESULTS: Bile acids robustly stimulate secretion of not only the incretin hormones, glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP-1), but also glucagon and insulin in vivo, to levels comparable to those resulting from glucose stimulation. The mechanisms of GLP-1, neurotensin, and peptide YY (PYY) secretion was secondary to intestinal absorption and depended on activation of basolateral membrane Takeda G-protein receptor 5 (TGR5) receptors on the L-cells in the following order of potency: Lithocholic acid (LCA) >Deoxycholicacid (DCA)>Chenodeoxycholicacid (CDCA)> Cholic acid (CA). Thus BAs did not stimulate secretion of GLP-1 and PYY from perfused small intestine in TGR5 KO mice but stimulated robust responses in wild type littermates. TGR5 is not expressed on α-cells or β-cells, and BAs had no direct effects on glucagon or insulin secretion from the perfused pancreas. CONCLUSION: BAs should be considered not only as fat emulsifiers but also as important regulators of appetite- and metabolism-regulating hormones by activation of basolateral intestinal TGR5.

KW - Bile-acids

KW - GLP-1

KW - Insulin

KW - Neurotensin

KW - PYY

KW - TGR5

U2 - 10.1016/j.molmet.2018.03.007

DO - 10.1016/j.molmet.2018.03.007

M3 - Journal article

VL - 11

SP - 84

EP - 95

JO - Molecular Metabolism

JF - Molecular Metabolism

SN - 2212-8778

ER -

ID: 195192727