Basal hyperaemia is the primary abnormality of perfusion in Takotsubo cardiomyopathy: a quantitative cardiac perfusion positron emission tomography study
Research output: Contribution to journal › Journal article › Research › peer-review
Thomas Emil Christensen, Kiril Aleksov Ahtarovski, Lia Evi Bang, Lene Holmvang, Helle Søholm, Adam Ali Ghotbi, Hedvig Andersson, Niels Vejlstrup, Nikolaj Ihlemann, Thomas Engstrøm, Andreas Kjær, Philip Hasbak
AIMS: Takotsubo cardiomyopathy (TTC) is characterized by acute completely reversible regional left ventricle (LV) akinesia and decreased tracer uptake in the akinetic region on semi-quantitative perfusion imaging. The latter may be due to normoperfusion of the akinetic mid/apical area and basal hyperperfusion. Our aim was to examine abnormalities of perfusion in TTC, and we hypothesized that basal hyperperfusion is the primary perfusion abnormality in the acute state.
METHOD AND RESULTS: Twenty-five patients were diagnosed with TTC due to (i) acute onset of symptoms, (ii) typical apical ballooning, (iii) absence of significant coronary disease, and (iv) complete remission on 4-month follow-up. The patients underwent coronary angiography (CAG), echocardiography, cardiac magnetic resonance imaging (CMR), and (13)NH3/(82)Rb positron emission tomography (PET) in the acute state and-except CAG-on follow-up. Patients initially had severe heart failure, mid/apical oedema but no infarction, and a rise in cardiac biomarkers. On initial perfusion PET imaging, eight patients appeared to have normal, whereas 17 patients had impaired LV perfusion. In the latter, flow in the basal region was increased in the acute state (1.5 ± 0.1 vs. 1.2 ± 0.1 mL/g/minRPP-corrected, P < 0.01), whereas midventricular (1.7 ± 0.1 vs. 1.6 ± 0.1 mL/g/minRPP-corrected, P = 0.21) and apical (1.4 ± 0.1 vs. 1.5 ± 0.1 mL/g/minRPP-corrected, P = 0.36) flow was unchanged between acute and follow-up, and within normal range.
CONCLUSION: Our results suggest an abnormal LV perfusion distribution in the acute state of TTC with basal hyperperfusion and a normoperfused akinetic region. The proportion of patients without visualized perfusion abnormalities in the acute state may represent a subgroup with fast remission.
|Journal||European Heart Journal Cardiovascular Imaging|
|Number of pages||8|
|Publication status||Published - Oct 2015|
- Aged, Biomarkers, Coronary Angiography, Echocardiography, Electrocardiography, Female, Humans, Hyperemia, Magnetic Resonance Imaging, Male, Myocardial Perfusion Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Rubidium Radioisotopes, Takotsubo Cardiomyopathy, Ventricular Dysfunction, Left