Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes

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Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. / Ramos-Lopez, Omar; Riezu-Boj, Jose I.; Milagro, Fermin I.; Zulet, M. Angeles; Santos, Jose L.; Martinez, J. Alfredo; Astrup, Arne; Larsen, Thomas Meinert; MENA Project.

In: Genes & Nutrition, Vol. 14, 11, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ramos-Lopez, O, Riezu-Boj, JI, Milagro, FI, Zulet, MA, Santos, JL, Martinez, JA, Astrup, A, Larsen, TM & MENA Project 2019, 'Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes', Genes & Nutrition, vol. 14, 11. https://doi.org/10.1186/s12263-019-0635-9

APA

Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., Zulet, M. A., Santos, J. L., Martinez, J. A., ... MENA Project (2019). Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. Genes & Nutrition, 14, [11]. https://doi.org/10.1186/s12263-019-0635-9

Vancouver

Ramos-Lopez O, Riezu-Boj JI, Milagro FI, Zulet MA, Santos JL, Martinez JA et al. Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. Genes & Nutrition. 2019;14. 11. https://doi.org/10.1186/s12263-019-0635-9

Author

Ramos-Lopez, Omar ; Riezu-Boj, Jose I. ; Milagro, Fermin I. ; Zulet, M. Angeles ; Santos, Jose L. ; Martinez, J. Alfredo ; Astrup, Arne ; Larsen, Thomas Meinert ; MENA Project. / Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. In: Genes & Nutrition. 2019 ; Vol. 14.

Bibtex

@article{0b924b6a348b4f9a8d9b5fb23a9c21d1,
title = "Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes",
abstract = "Background: Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, obesity features, and dietary intakes. Methods: A nutriepigenomic analysis was conducted in 474 adults from the Methyl Epigenome Network Association (MENA) project. Anthropometric measurements, clinical data, and serum metabolic profiles of the study population were obtained from structured databases of the MENA cohorts. Habitual dietary intake was assessed using a validated semiquantitative food frequency questionnaire. DNA methylation was measured in circulating white blood cells by microarray (Infinium Human Methylation 450 K BeadChips). FDR values (p < 0.0001) were used to select those CpGs that showed the best correlation with body mass index (BMI) and waist circumference (WC). Pathway analyses involving the characterization of genes involved in the olfactory transduction system were performed using KEGG and pathDIP reference databases. Results: Overall, 15 CpG sites at olfactory pathway genes were associated with BMI (p < 0.0001) and WC (p < 0.0001) after adjustments for potential confounding factors. Together, methylation levels at the15 CpG sites accounted for 22{\%} and 20{\%} of the variability in BMI and WC (r 2 = 0.219, p < 0.001, and r 2 = 0.204, p < 0.001, respectively). These genes encompassed olfactory receptors (OR4D2, OR51A7, OR2T34, and OR2Y1) and several downstream signaling molecules (SLC8A1, ANO2, PDE2A, CALML3, GNG7, CALML6, PRKG1, and CAMK2D), which significantly regulated odor detection and signal transduction processes within the complete olfactory cascade, as revealed by pathway enrichment analyses (p = 1.94 × 10 -10 ). Moreover, OR4D2 and OR2Y1 gene methylation patterns strongly correlated with daily intakes of total energy (p < 0.0001), carbohydrates (p < 0.0001), protein (p < 0.0001), and fat (p < 0.0001).Conclusions: The results of this study suggest novel relationships between olfactory pathway gene methylation signatures, obesity indices, and dietary intakes.",
keywords = "Diet, Epigenetics, Olfactory system, OR2Y1, OR4D2, Smell",
author = "Omar Ramos-Lopez and Riezu-Boj, {Jose I.} and Milagro, {Fermin I.} and Zulet, {M. Angeles} and Santos, {Jose L.} and Martinez, {J. Alfredo} and A. Alonso and C. Arancibia and F. Ar{\'o}s and Arne Astrup and N. Babio and V. Bl{\'a}zquez and I. Bondia-Pons and L. Brennan and P. Buil-Cosiales and J. Campi{\'o}n and Cataldo, {L. R.} and C. Celis-Morales and D. Corella and Covas, {M. I.} and S. Dalskov and H. Daniel and {De Arce}, A. and {De La Iglesia}, R. and R. Estruch and J. Fern{\'a}ndez-Crehuet and M. Fiol and M. Fit{\'o} and M. Flores and L. Forga and J. Galgani and Gibney, {E. R.} and Gibney, {M. J.} and G{\'o}mez-{\'U}riz, {A. M.} and P. Gonz{\'a}lez-Muniesa and E. Goyenechea and B. Guy-Grand and T. Handjieva-Darlenska and C. Holst and Huerta, {A. E.} and S. Jebb and A. Kafatos and Larsen, {Thomas Meinert} and O. Pedersen and M. Petersen and A. Pfeiffer and S{\o}rensen, {Thorkild I. A.} and Sorl{\'i}, {J. V.} and S. Toubro and C. Verdich and {MENA Project}",
note = "CURIS 2019 NEXS 169",
year = "2019",
doi = "10.1186/s12263-019-0635-9",
language = "English",
volume = "14",
journal = "Genes & Nutrition",
issn = "1555-8932",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes

AU - Ramos-Lopez, Omar

AU - Riezu-Boj, Jose I.

AU - Milagro, Fermin I.

AU - Zulet, M. Angeles

AU - Santos, Jose L.

AU - Martinez, J. Alfredo

AU - Alonso, A.

AU - Arancibia, C.

AU - Arós, F.

AU - Astrup, Arne

AU - Babio, N.

AU - Blázquez, V.

AU - Bondia-Pons, I.

AU - Brennan, L.

AU - Buil-Cosiales, P.

AU - Campión, J.

AU - Cataldo, L. R.

AU - Celis-Morales, C.

AU - Corella, D.

AU - Covas, M. I.

AU - Dalskov, S.

AU - Daniel, H.

AU - De Arce, A.

AU - De La Iglesia, R.

AU - Estruch, R.

AU - Fernández-Crehuet, J.

AU - Fiol, M.

AU - Fitó, M.

AU - Flores, M.

AU - Forga, L.

AU - Galgani, J.

AU - Gibney, E. R.

AU - Gibney, M. J.

AU - Gómez-Úriz, A. M.

AU - González-Muniesa, P.

AU - Goyenechea, E.

AU - Guy-Grand, B.

AU - Handjieva-Darlenska, T.

AU - Holst, C.

AU - Huerta, A. E.

AU - Jebb, S.

AU - Kafatos, A.

AU - Larsen, Thomas Meinert

AU - Pedersen, O.

AU - Petersen, M.

AU - Pfeiffer, A.

AU - Sørensen, Thorkild I. A.

AU - Sorlí, J. V.

AU - Toubro, S.

AU - Verdich, C.

AU - MENA Project

N1 - CURIS 2019 NEXS 169

PY - 2019

Y1 - 2019

N2 - Background: Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, obesity features, and dietary intakes. Methods: A nutriepigenomic analysis was conducted in 474 adults from the Methyl Epigenome Network Association (MENA) project. Anthropometric measurements, clinical data, and serum metabolic profiles of the study population were obtained from structured databases of the MENA cohorts. Habitual dietary intake was assessed using a validated semiquantitative food frequency questionnaire. DNA methylation was measured in circulating white blood cells by microarray (Infinium Human Methylation 450 K BeadChips). FDR values (p < 0.0001) were used to select those CpGs that showed the best correlation with body mass index (BMI) and waist circumference (WC). Pathway analyses involving the characterization of genes involved in the olfactory transduction system were performed using KEGG and pathDIP reference databases. Results: Overall, 15 CpG sites at olfactory pathway genes were associated with BMI (p < 0.0001) and WC (p < 0.0001) after adjustments for potential confounding factors. Together, methylation levels at the15 CpG sites accounted for 22% and 20% of the variability in BMI and WC (r 2 = 0.219, p < 0.001, and r 2 = 0.204, p < 0.001, respectively). These genes encompassed olfactory receptors (OR4D2, OR51A7, OR2T34, and OR2Y1) and several downstream signaling molecules (SLC8A1, ANO2, PDE2A, CALML3, GNG7, CALML6, PRKG1, and CAMK2D), which significantly regulated odor detection and signal transduction processes within the complete olfactory cascade, as revealed by pathway enrichment analyses (p = 1.94 × 10 -10 ). Moreover, OR4D2 and OR2Y1 gene methylation patterns strongly correlated with daily intakes of total energy (p < 0.0001), carbohydrates (p < 0.0001), protein (p < 0.0001), and fat (p < 0.0001).Conclusions: The results of this study suggest novel relationships between olfactory pathway gene methylation signatures, obesity indices, and dietary intakes.

AB - Background: Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, obesity features, and dietary intakes. Methods: A nutriepigenomic analysis was conducted in 474 adults from the Methyl Epigenome Network Association (MENA) project. Anthropometric measurements, clinical data, and serum metabolic profiles of the study population were obtained from structured databases of the MENA cohorts. Habitual dietary intake was assessed using a validated semiquantitative food frequency questionnaire. DNA methylation was measured in circulating white blood cells by microarray (Infinium Human Methylation 450 K BeadChips). FDR values (p < 0.0001) were used to select those CpGs that showed the best correlation with body mass index (BMI) and waist circumference (WC). Pathway analyses involving the characterization of genes involved in the olfactory transduction system were performed using KEGG and pathDIP reference databases. Results: Overall, 15 CpG sites at olfactory pathway genes were associated with BMI (p < 0.0001) and WC (p < 0.0001) after adjustments for potential confounding factors. Together, methylation levels at the15 CpG sites accounted for 22% and 20% of the variability in BMI and WC (r 2 = 0.219, p < 0.001, and r 2 = 0.204, p < 0.001, respectively). These genes encompassed olfactory receptors (OR4D2, OR51A7, OR2T34, and OR2Y1) and several downstream signaling molecules (SLC8A1, ANO2, PDE2A, CALML3, GNG7, CALML6, PRKG1, and CAMK2D), which significantly regulated odor detection and signal transduction processes within the complete olfactory cascade, as revealed by pathway enrichment analyses (p = 1.94 × 10 -10 ). Moreover, OR4D2 and OR2Y1 gene methylation patterns strongly correlated with daily intakes of total energy (p < 0.0001), carbohydrates (p < 0.0001), protein (p < 0.0001), and fat (p < 0.0001).Conclusions: The results of this study suggest novel relationships between olfactory pathway gene methylation signatures, obesity indices, and dietary intakes.

KW - Diet

KW - Epigenetics

KW - Olfactory system

KW - OR2Y1

KW - OR4D2

KW - Smell

UR - http://www.scopus.com/inward/record.url?scp=85065243457&partnerID=8YFLogxK

U2 - 10.1186/s12263-019-0635-9

DO - 10.1186/s12263-019-0635-9

M3 - Journal article

VL - 14

JO - Genes & Nutrition

JF - Genes & Nutrition

SN - 1555-8932

M1 - 11

ER -

ID: 218393650