Association between an interleukin-13 promoter polymorphism and atopy
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Several studies indicate genetic involvement of Th2 cytokines in allergic diseases. Interleukin (IL)-13 has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Recently, an association was reported between the T allele in a promoter polymorphism in the IL-13 gene (C to T exchange) at position -1055 and allergic asthma in a population study in the Netherlands. This observation was apparently confirmed in a case-control study using probands and spouses from a Dutch asthma family study, but the polymorphism in that study was reported to occur at position -1111. In the present study, we established that this polymorphism is located at position -1024 relative to the ATG translation initiation codon, and investigated whether it confers a genetic predisposition to atopic conditions and the Th1 condition multiple sclerosis (MS) in Caucasian subjects. We confirmed the association between the IL-13 -1024TT genoype and inhalation allergy (P = 2.4E-02). By combining the data from the three studies, we demonstrated a strong association (P = 1.09E-05) between the IL-13 -1024 marker and inhalation allergy. Furthermore, we showed for the first time that this association also exists in atopic dermatitis (P = 2.0E-02). No association with MS was found.
|Journal||European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics|
|Number of pages||5|
|Publication status||Published - Oct 2003|
- Base Sequence, Genetic Predisposition to Disease, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Interleukin-13, Molecular Sequence Data, Multiple Sclerosis, Polymerase Chain Reaction, Polymorphism, Genetic, Promoter Regions, Genetic, Th1 Cells, Th2 Cells