Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest : A Nationwide Case-Time-Control Study. / Weeke, P; Jensen, Aksel Karl Georg; Folke, F; Gislason, G H; Olesen, J B; Andersson, C; Fosbøl, E L; Larsen, J K; Lippert, Freddy; Nielsen, S L; Gerds, Thomas Alexander; Andersen, Per Kragh; Kanters, Jørgen K.; Poulsen, H E; Pehrson, S; Køber, L; Torp-Pedersen, C.

In: Clinical Pharmacology and Therapeutics, Vol. 92, No. 1, 2012, p. 72-79.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Weeke, P, Jensen, AKG, Folke, F, Gislason, GH, Olesen, JB, Andersson, C, Fosbøl, EL, Larsen, JK, Lippert, F, Nielsen, SL, Gerds, TA, Andersen, PK, Kanters, JK, Poulsen, HE, Pehrson, S, Køber, L & Torp-Pedersen, C 2012, 'Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study', Clinical Pharmacology and Therapeutics, vol. 92, no. 1, pp. 72-79. https://doi.org/10.1038/clpt.2011.368

APA

Weeke, P., Jensen, A. K. G., Folke, F., Gislason, G. H., Olesen, J. B., Andersson, C., ... Torp-Pedersen, C. (2012). Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study. Clinical Pharmacology and Therapeutics, 92(1), 72-79. https://doi.org/10.1038/clpt.2011.368

Vancouver

Weeke P, Jensen AKG, Folke F, Gislason GH, Olesen JB, Andersson C et al. Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study. Clinical Pharmacology and Therapeutics. 2012;92(1):72-79. https://doi.org/10.1038/clpt.2011.368

Author

Weeke, P ; Jensen, Aksel Karl Georg ; Folke, F ; Gislason, G H ; Olesen, J B ; Andersson, C ; Fosbøl, E L ; Larsen, J K ; Lippert, Freddy ; Nielsen, S L ; Gerds, Thomas Alexander ; Andersen, Per Kragh ; Kanters, Jørgen K. ; Poulsen, H E ; Pehrson, S ; Køber, L ; Torp-Pedersen, C. / Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest : A Nationwide Case-Time-Control Study. In: Clinical Pharmacology and Therapeutics. 2012 ; Vol. 92, No. 1. pp. 72-79.

Bibtex

@article{8ca119b67154431f88b3736af947aa8e,
title = "Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study",
abstract = "Treatment with some types of antidepressants has been associated with sudden cardiac death. It is unknown whether the increased risk is due to a class effect or related to specific antidepressants within drug classes. All patients in Denmark with an out-of-hospital cardiac arrest (OHCA) were identified (2001-2007). Association between treatment with specific antidepressants and OHCA was examined by conditional logistic regression in case-time-control models. We identified 19,110 patients with an OHCA; 2,913 (15.2{\%}) were receiving antidepressant treatment at the time of OHCA, with citalopram being the most frequently used type of antidepressant (50.8{\%}). Tricyclic antidepressants (TCAs; odds ratio (OR) = 1.69, confidence interval (CI): 1.14-2.50) and selective serotonin reuptake inhibitors (SSRIs; OR = 1.21, CI: 1.00-1.47) were both associated with comparable increases in risk of OHCA, whereas no association was found for serotonin-norepinephrine reuptake inhibitors/noradrenergic and specific serotonergic antidepressants (SNRIs/NaSSAs; OR = 1.06, CI: 0.81-1.39). The increased risks were primarily driven by: citalopram (OR = 1.29, CI: 1.02-1.63) and nortriptyline (OR = 5.14, CI: 2.17-12.2). An association between cardiac arrest and antidepressant use could be documented in both the SSRI and TCA classes of drugs.",
author = "P Weeke and Jensen, {Aksel Karl Georg} and F Folke and Gislason, {G H} and Olesen, {J B} and C Andersson and Fosb{\o}l, {E L} and Larsen, {J K} and Freddy Lippert and Nielsen, {S L} and Gerds, {Thomas Alexander} and Andersen, {Per Kragh} and Kanters, {J{\o}rgen K.} and Poulsen, {H E} and S Pehrson and L K{\o}ber and C Torp-Pedersen",
year = "2012",
doi = "10.1038/clpt.2011.368",
language = "English",
volume = "92",
pages = "72--79",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest

T2 - A Nationwide Case-Time-Control Study

AU - Weeke, P

AU - Jensen, Aksel Karl Georg

AU - Folke, F

AU - Gislason, G H

AU - Olesen, J B

AU - Andersson, C

AU - Fosbøl, E L

AU - Larsen, J K

AU - Lippert, Freddy

AU - Nielsen, S L

AU - Gerds, Thomas Alexander

AU - Andersen, Per Kragh

AU - Kanters, Jørgen K.

AU - Poulsen, H E

AU - Pehrson, S

AU - Køber, L

AU - Torp-Pedersen, C

PY - 2012

Y1 - 2012

N2 - Treatment with some types of antidepressants has been associated with sudden cardiac death. It is unknown whether the increased risk is due to a class effect or related to specific antidepressants within drug classes. All patients in Denmark with an out-of-hospital cardiac arrest (OHCA) were identified (2001-2007). Association between treatment with specific antidepressants and OHCA was examined by conditional logistic regression in case-time-control models. We identified 19,110 patients with an OHCA; 2,913 (15.2%) were receiving antidepressant treatment at the time of OHCA, with citalopram being the most frequently used type of antidepressant (50.8%). Tricyclic antidepressants (TCAs; odds ratio (OR) = 1.69, confidence interval (CI): 1.14-2.50) and selective serotonin reuptake inhibitors (SSRIs; OR = 1.21, CI: 1.00-1.47) were both associated with comparable increases in risk of OHCA, whereas no association was found for serotonin-norepinephrine reuptake inhibitors/noradrenergic and specific serotonergic antidepressants (SNRIs/NaSSAs; OR = 1.06, CI: 0.81-1.39). The increased risks were primarily driven by: citalopram (OR = 1.29, CI: 1.02-1.63) and nortriptyline (OR = 5.14, CI: 2.17-12.2). An association between cardiac arrest and antidepressant use could be documented in both the SSRI and TCA classes of drugs.

AB - Treatment with some types of antidepressants has been associated with sudden cardiac death. It is unknown whether the increased risk is due to a class effect or related to specific antidepressants within drug classes. All patients in Denmark with an out-of-hospital cardiac arrest (OHCA) were identified (2001-2007). Association between treatment with specific antidepressants and OHCA was examined by conditional logistic regression in case-time-control models. We identified 19,110 patients with an OHCA; 2,913 (15.2%) were receiving antidepressant treatment at the time of OHCA, with citalopram being the most frequently used type of antidepressant (50.8%). Tricyclic antidepressants (TCAs; odds ratio (OR) = 1.69, confidence interval (CI): 1.14-2.50) and selective serotonin reuptake inhibitors (SSRIs; OR = 1.21, CI: 1.00-1.47) were both associated with comparable increases in risk of OHCA, whereas no association was found for serotonin-norepinephrine reuptake inhibitors/noradrenergic and specific serotonergic antidepressants (SNRIs/NaSSAs; OR = 1.06, CI: 0.81-1.39). The increased risks were primarily driven by: citalopram (OR = 1.29, CI: 1.02-1.63) and nortriptyline (OR = 5.14, CI: 2.17-12.2). An association between cardiac arrest and antidepressant use could be documented in both the SSRI and TCA classes of drugs.

U2 - 10.1038/clpt.2011.368

DO - 10.1038/clpt.2011.368

M3 - Journal article

VL - 92

SP - 72

EP - 79

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 1

ER -

ID: 40155476