Amitriptyline versus placebo for major depression
Research output: Contribution to journal › Journal article › Research › peer-review
Lars Vedel Kessing, Jens Otto Drachmann Bukh
A recent Cochrane review concluded that amitriptyline is an efficacious antidepressant drug, however associated with a number of side effects. The present paper discusses this finding in relation to studies on effects and side effects of SSRIs and dual-action drugs. It is concluded that there is some evidence for recommending treatment with tricyclic antidepressants (TCA) especially in patients who are hospitalized with severe depression and melancholic features. Further, nortriptylin is preferred due to its more favourable side effects profile.
|Journal||Ugeskrift for Laeger|
|Number of pages||3|
|Publication status||Published - 19 Aug 2013|