Added value of IP-10 as a read-out of Mycobacterium tuberculosis: Specific immunity in young children

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Synne Jenum, Sivmakumaran Dhanasekaran, Christian Ritz, Ragini Macaden, T Mark Doherty, Harleen M.S. Grewal, TB Trials Study Group

We have explored the added value of IFNγ-inducible protein 10 as a read-out of Mycobacterium tuberculosis specific immunity in young Indian children where the sensitivity of the IGRA for tuberculosis (TB) is poor. Reduced frequency of indeterminate results and an increased sensitivity for TB, suggest a potential for fewer missed cases with a combined IFNγ/IP-10 read-out in a 4 generation IGRA.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Original languageEnglish
JournalPediatric Infectious Disease Journal
Issue number12
Pages (from-to)1336-1338
Number of pages3
Publication statusPublished - 2016

    Research areas

  • The Faculty of Science - Tuberculosis, Child, Tuberculin skin test, Interferon-gamma release assay, Cytokines, Chemokines

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