A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. / Bouatia-Naji, Nabila; Bonnefond, Amélie; Cavalcanti-Proença, Christine; Sparsø, Thomas; Holmkvist, Johan; Marchand, Marion; Delplanque, Jérôme; Lobbens, Stéphane; Rocheleau, Ghislain; Durand, Emmanuelle; De Graeve, Franck; Chèvre, Jean-Claude; Borch-Johnsen, Knut; Hartikainen, Anna-Liisa; Ruokonen, Aimo; Tichet, Jean; Marre, Michel; Weill, Jacques; Heude, Barbara; Tauber, Maithé; Lemaire, Katleen; Schuit, Frans; Elliott, Paul; Jørgensen, Torben; Charpentier, Guillaume; Hadjadj, Samy; Cauchi, Stéphane; Vaxillaire, Martine; Sladek, Robert; Visvikis-Siest, Sophie; Balkau, Beverley; Lévy-Marchal, Claire; Pattou, François; Meyre, David; Blakemore, Alexandra I F; Jarvelin, Marjo-Riita; Walley, Andrew J; Hansen, Torben; Dina, Christian; Pedersen, Oluf; Froguel, Philippe.

In: Nature Genetics, Vol. 41, No. 1, 2009, p. 89-94.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bouatia-Naji, N, Bonnefond, A, Cavalcanti-Proença, C, Sparsø, T, Holmkvist, J, Marchand, M, Delplanque, J, Lobbens, S, Rocheleau, G, Durand, E, De Graeve, F, Chèvre, J-C, Borch-Johnsen, K, Hartikainen, A-L, Ruokonen, A, Tichet, J, Marre, M, Weill, J, Heude, B, Tauber, M, Lemaire, K, Schuit, F, Elliott, P, Jørgensen, T, Charpentier, G, Hadjadj, S, Cauchi, S, Vaxillaire, M, Sladek, R, Visvikis-Siest, S, Balkau, B, Lévy-Marchal, C, Pattou, F, Meyre, D, Blakemore, AIF, Jarvelin, M-R, Walley, AJ, Hansen, T, Dina, C, Pedersen, O & Froguel, P 2009, 'A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk', Nature Genetics, vol. 41, no. 1, pp. 89-94. https://doi.org/10.1038/ng.277

APA

Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., ... Froguel, P. (2009). A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nature Genetics, 41(1), 89-94. https://doi.org/10.1038/ng.277

Vancouver

Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nature Genetics. 2009;41(1):89-94. https://doi.org/10.1038/ng.277

Author

Bouatia-Naji, Nabila ; Bonnefond, Amélie ; Cavalcanti-Proença, Christine ; Sparsø, Thomas ; Holmkvist, Johan ; Marchand, Marion ; Delplanque, Jérôme ; Lobbens, Stéphane ; Rocheleau, Ghislain ; Durand, Emmanuelle ; De Graeve, Franck ; Chèvre, Jean-Claude ; Borch-Johnsen, Knut ; Hartikainen, Anna-Liisa ; Ruokonen, Aimo ; Tichet, Jean ; Marre, Michel ; Weill, Jacques ; Heude, Barbara ; Tauber, Maithé ; Lemaire, Katleen ; Schuit, Frans ; Elliott, Paul ; Jørgensen, Torben ; Charpentier, Guillaume ; Hadjadj, Samy ; Cauchi, Stéphane ; Vaxillaire, Martine ; Sladek, Robert ; Visvikis-Siest, Sophie ; Balkau, Beverley ; Lévy-Marchal, Claire ; Pattou, François ; Meyre, David ; Blakemore, Alexandra I F ; Jarvelin, Marjo-Riita ; Walley, Andrew J ; Hansen, Torben ; Dina, Christian ; Pedersen, Oluf ; Froguel, Philippe. / A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. In: Nature Genetics. 2009 ; Vol. 41, No. 1. pp. 89-94.

Bibtex

@article{bbef570019ea11deb43e000ea68e967b,
title = "A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk",
abstract = "In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95{\%} CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95{\%} CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.",
author = "Nabila Bouatia-Naji and Am{\'e}lie Bonnefond and Christine Cavalcanti-Proen{\cc}a and Thomas Spars{\o} and Johan Holmkvist and Marion Marchand and J{\'e}r{\^o}me Delplanque and St{\'e}phane Lobbens and Ghislain Rocheleau and Emmanuelle Durand and {De Graeve}, Franck and Jean-Claude Ch{\`e}vre and Knut Borch-Johnsen and Anna-Liisa Hartikainen and Aimo Ruokonen and Jean Tichet and Michel Marre and Jacques Weill and Barbara Heude and Maith{\'e} Tauber and Katleen Lemaire and Frans Schuit and Paul Elliott and Torben J{\o}rgensen and Guillaume Charpentier and Samy Hadjadj and St{\'e}phane Cauchi and Martine Vaxillaire and Robert Sladek and Sophie Visvikis-Siest and Beverley Balkau and Claire L{\'e}vy-Marchal and Fran{\cc}ois Pattou and David Meyre and Blakemore, {Alexandra I F} and Marjo-Riita Jarvelin and Walley, {Andrew J} and Torben Hansen and Christian Dina and Oluf Pedersen and Philippe Froguel",
note = "Keywords: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Blood Glucose; Child; Chromosomes, Human, Pair 11; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucokinase; Humans; Insulin Resistance; Islets of Langerhans; Meta-Analysis as Topic; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Receptor, Melatonin, MT2; Receptors, Melatonin; Reproducibility of Results",
year = "2009",
doi = "10.1038/ng.277",
language = "English",
volume = "41",
pages = "89--94",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

AU - Bouatia-Naji, Nabila

AU - Bonnefond, Amélie

AU - Cavalcanti-Proença, Christine

AU - Sparsø, Thomas

AU - Holmkvist, Johan

AU - Marchand, Marion

AU - Delplanque, Jérôme

AU - Lobbens, Stéphane

AU - Rocheleau, Ghislain

AU - Durand, Emmanuelle

AU - De Graeve, Franck

AU - Chèvre, Jean-Claude

AU - Borch-Johnsen, Knut

AU - Hartikainen, Anna-Liisa

AU - Ruokonen, Aimo

AU - Tichet, Jean

AU - Marre, Michel

AU - Weill, Jacques

AU - Heude, Barbara

AU - Tauber, Maithé

AU - Lemaire, Katleen

AU - Schuit, Frans

AU - Elliott, Paul

AU - Jørgensen, Torben

AU - Charpentier, Guillaume

AU - Hadjadj, Samy

AU - Cauchi, Stéphane

AU - Vaxillaire, Martine

AU - Sladek, Robert

AU - Visvikis-Siest, Sophie

AU - Balkau, Beverley

AU - Lévy-Marchal, Claire

AU - Pattou, François

AU - Meyre, David

AU - Blakemore, Alexandra I F

AU - Jarvelin, Marjo-Riita

AU - Walley, Andrew J

AU - Hansen, Torben

AU - Dina, Christian

AU - Pedersen, Oluf

AU - Froguel, Philippe

N1 - Keywords: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Blood Glucose; Child; Chromosomes, Human, Pair 11; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucokinase; Humans; Insulin Resistance; Islets of Langerhans; Meta-Analysis as Topic; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Receptor, Melatonin, MT2; Receptors, Melatonin; Reproducibility of Results

PY - 2009

Y1 - 2009

N2 - In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.

AB - In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.

U2 - 10.1038/ng.277

DO - 10.1038/ng.277

M3 - Journal article

VL - 41

SP - 89

EP - 94

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -

ID: 11550950