A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

Research output: Contribution to journalJournal articleResearchpeer-review

C S Rose, N Grarup, N T Krarup, P Poulsen, L Wegner, Trine Nielsen, K Banasik, K Faerch, G Andersen, A Albrechtsen, K Borch-Johnsen, J O Clausen, T Jørgensen, A Vaag, O Pedersen, T Hansen

An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
Original languageEnglish
JournalDiabetologia
Volume52
Issue number10
Pages (from-to)2122-2129
Number of pages8
ISSN0012-186X
DOIs
Publication statusPublished - 2009

    Research areas

  • ATP-Binding Cassette Transporters, Adult, Blood Glucose, Fasting, Female, Genotype, Glucose, Glucose Tolerance Test, Glucose-6-Phosphatase, Humans, Insulin, Liver, Male, Middle Aged

ID: 20686026