A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. / Hubel, Philipp; Urban, Christian; Bergant, Valter; Schneider, William M; Knauer, Barbara; Stukalov, Alexey; Scaturro, Pietro; Mann, Angelika; Brunotte, Linda; Hoffmann, Heinrich H; Schoggins, John W; Schwemmle, Martin; Mann, Matthias; Rice, Charles M; Pichlmair, Andreas.

In: Nature Immunology, 04.03.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hubel, P, Urban, C, Bergant, V, Schneider, WM, Knauer, B, Stukalov, A, Scaturro, P, Mann, A, Brunotte, L, Hoffmann, HH, Schoggins, JW, Schwemmle, M, Mann, M, Rice, CM & Pichlmair, A 2019, 'A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape', Nature Immunology. https://doi.org/10.1038/s41590-019-0323-3

APA

Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., ... Pichlmair, A. (2019). A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature Immunology. https://doi.org/10.1038/s41590-019-0323-3

Vancouver

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A et al. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature Immunology. 2019 Mar 4. https://doi.org/10.1038/s41590-019-0323-3

Author

Hubel, Philipp ; Urban, Christian ; Bergant, Valter ; Schneider, William M ; Knauer, Barbara ; Stukalov, Alexey ; Scaturro, Pietro ; Mann, Angelika ; Brunotte, Linda ; Hoffmann, Heinrich H ; Schoggins, John W ; Schwemmle, Martin ; Mann, Matthias ; Rice, Charles M ; Pichlmair, Andreas. / A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. In: Nature Immunology. 2019.

Bibtex

@article{49d829f53f454094b0c136c6a4085729,
title = "A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape",
abstract = "Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90{\%} of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.",
author = "Philipp Hubel and Christian Urban and Valter Bergant and Schneider, {William M} and Barbara Knauer and Alexey Stukalov and Pietro Scaturro and Angelika Mann and Linda Brunotte and Hoffmann, {Heinrich H} and Schoggins, {John W} and Martin Schwemmle and Matthias Mann and Rice, {Charles M} and Andreas Pichlmair",
year = "2019",
month = "3",
day = "4",
doi = "10.1038/s41590-019-0323-3",
language = "English",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

AU - Hubel, Philipp

AU - Urban, Christian

AU - Bergant, Valter

AU - Schneider, William M

AU - Knauer, Barbara

AU - Stukalov, Alexey

AU - Scaturro, Pietro

AU - Mann, Angelika

AU - Brunotte, Linda

AU - Hoffmann, Heinrich H

AU - Schoggins, John W

AU - Schwemmle, Martin

AU - Mann, Matthias

AU - Rice, Charles M

AU - Pichlmair, Andreas

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.

AB - Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.

U2 - 10.1038/s41590-019-0323-3

DO - 10.1038/s41590-019-0323-3

M3 - Journal article

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

ER -

ID: 214462915