A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians
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Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians.
|Number of pages||6|
|Publication status||Published - 2005|
- Adolescent, Adult, Age Distribution, Age of Onset, Asian Continental Ancestry Group, Child, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-alpha, Humans, India, Middle Aged, Polymorphism, Single Nucleotide, Prevalence