A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

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Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jacob Melgaard, Egon Toft, Stefan Kääb, Johannes J Struijk

The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume103
Issue number6
Pages (from-to)1100-1106
Number of pages7
ISSN0009-9236
DOIs
Publication statusPublished - 2018

ID: 189664609