Thue W. Schwartz

Thue W. Schwartz

Professor

  • NNF Center for Basic Metabolic Research

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85


  1. 2019
  2. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. / Lückmann, Michael; Trauelsen, Mette; Bentsen, Marie A; Nissen, Tinne A D; Martins, Joao; Fallah, Zohreh; Nygaard, Mads M; Papaleo, Elena; Lindorff-Larsen, Kresten; Schwartz, Thue W; Frimurer, Thomas M.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 14, 02.04.2019, p. 7123-7128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity. / Arora, Tulika; Rudenko, Olga; Egerod, Kristoffer Lihme; Husted, Anna Sofie; Kovatcheva-Datchary, Petia; Akrami, Rozita; Kristensen, Mette; Schwartz, Thue W.; Backhed, Fredrik.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 316, No. 3, 03.2019, p. E453-E463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. / Chen, Shuanghong; Lu, Mengjie; Liu, Dongsheng; Yang, Lingyun; Yi, Cuiying; Ma, Limin; Zhang, Hui; Liu, Qing; Frimurer, Thomas M.; Wang, Ming-Wei; Schwartz, Thue W.; Stevens, Raymond C.; Wu, Beili; Wuthrich, Kurt; Zhao, Qiang.

    In: Nature Communications, Vol. 10, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. / Riis, Simon; Christensen, Britt; Nellemann, Birgitte; Moller, Andreas Ruch; Husted, Anna Sofie; Pedersen, Steen B.; Schwartz, Thue W.; Jorgensen, Jens Otto Lunde; Jessen, Niels.

    In: Journal of Applied Physiology, Vol. 126, No. 3, 2019, p. 569-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Preassociation between the 5-HT7 serotonin receptor and G protein G(s): molecular determinants and association with low potency activation of adenylyl cyclase. / Ulsund, Andrea Hembre; Dahl, Marie; Frimurer, Thomas M.; Manfra, Ornella; Schwartz, Thue W.; Levy, Finn Olav; Andressen, Kjetil Wessel.

    In: FASEB Journal, Vol. 33, No. 3, 2019, p. 3870-3886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. / Rudenko, Olga; Shang, Jin; Munk, Alexander; Ekberg, Jeppe P.; Petersen, Natalia; Engelstoft, Maja S; Egerod, Kristoffer L; Hjorth, Siv A; Wu, Margaret; Feng, Yue; Zhou, Yun-Ping; Mokrosinski, Jacek; Thams, Peter; Reimann, Frank; Gribble, Fiona; Rehfeld, Jens F; Holst, Jens J.; Treebak, Jonas T.; Howard, Andrew D; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 19, 2019, p. 49-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa. / Tough, Iain R; Forbes, Sarah; Herzog, Herbert; Jones, Robert M; Schwartz, Thue W; Cox, Helen M.

    In: Endocrinology, Vol. 159, No. 4, 19.02.2018, p. 1704-1717.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. / Lund, Mari L; Egerod, Kristoffer L; Engelstoft, Maja S; Dmytriyeva, Oksana; Theodorsson, Elvar; Patel, Bhavik A; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 11, 2018, p. 70-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published
  12. Published

    Microbial regulation of the L cell transcriptome. / Arora, Tulika; Akrami, Rozita; Pais, Ramona; Bergqvist, Linda; Johansson, Bengt R; Schwartz, Thue W.; Reimann, Frank; Gribble, Fiona M; Bäckhed, Fredrik.

    In: Scientific Reports, Vol. 8, 1207, 2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. / Egerod, Kristoffer L.; Petersen, Natalia; Timshel, Pascal N.; Rekling, Jens C.; Wang, Yibing; Liu, Qinghua; Schwartz, Thue W.; Gautron, Laurent.

    In: Molecular Metabolism, Vol. 12, 2018, p. 62-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1. / Rexen Ulven, Elisabeth; Trauelsen, Mette; Brvar, Matjaz; Lückmann, Michael; Bielefeldt, Line Ø; Jensen, Lisa K I; Schwartz, Thue W; Frimurer, Thomas M.

    In: Scientific Reports, Vol. 8, No. 1, 10010, 2018, p. 1-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The HETE Is on FFAR1 and Pancreatic Islet Cells. / Trauelsen, Mette; Lückmann, Michael; Frimurer, Thomas M; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 27, No. 2, 2018, p. 273-275.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2017
  17. Published

    Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91. / Trauelsen, Mette; Rexen Ulven, Elisabeth; Hjorth, Siv A; Brvar, Matjaz; Monaco, Claudia; Frimurer, Thomas M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 6, No. 12, 12.2017, p. 1585-1596.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Gq and Gs signaling acting in synergy to control GLP-1 secretion. / Pedersen, Maria Hauge; Ekberg, Jeppe Hvidtfeldt; Engelstoft, Maja Storm; Timshel, Pascal; Madsen, Andreas N; Schwartz, Thue W.

    In: Molecular and Cellular Endocrinology, Vol. 449, 07.2017, p. 64-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    GPCR-Mediated Signaling of Metabolites. / Husted, Anna Sofie; Trauelsen, Mette; Rudenko, Olga; Hjorth, Siv A; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 25, No. 4, 04.04.2017, p. 777-796.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies. / Niss Arfelt, Kristine; Barington, Line; Benned-Jensen, Tau; Kubale, Valentina; Kovalchuk, Alexander L; Daugvilaite, Viktorija; Pravsgaard Christensen, Jan; Randrup Thomsen, Allan; Egerod, Kristoffer L; Bassi, Maria R; Spiess, Katja; Schwartz, Thue W; Wang, Hongsheng; Morse, Herbert C; Holst, Peter J; Rosenkilde, Mette M.

    In: Blood, Vol. 129, No. 7, 2017, p. 866-878.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. / Frimurer, Thomas M.; Mende, Franziska; Graae, Anne-Sofie; Engelstoft, Maja S.; Egerod, Kristoffer L.; Nygaard, Rie; Gerlach, Lars-Ole; Hansen, Jakob Bondo; Schwartz, Thue W.; Holst, Birgitte.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 3, 2017, p. 886-898.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural biology: Full monty of family B GPCRs. / Schwartz, Thue W; Frimurer, Thomas M.

    In: Nature Chemical Biology, Vol. 13, No. 8, 2017, p. 819-821.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action. / Lückmann, Michael; Amarandi, Roxana-Maria; Papargyri, Natalia; Jakobsen, Mette H; Christiansen, Elisabeth; Jensen, Lars Juhl; Pui, Aurel; Schwartz, Thue W.; Rosenkilde, Mette Marie; Frimurer, Thomas Michael.

    In: Chemical Biology & Drug Design, Vol. 89, No. 3, 2017, p. 289–296.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2016
  25. Published

    High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice. / Thieme, V; Jolly, N; Madsen, A N; Bellmann-Sickert, K; Schwartz, T W; Holst, B; Cox, H M; Beck-Sickinger, A G.

    In: British Journal of Pharmacology, Vol. 173, No. 22, 11.2016, p. 3208-3221.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40). / Ekberg, Jeppe H; Pedersen, Maria Hauge; Kristensen, Line V; Madsen, Andreas N; Engelstoft, Maja S; Husted, Anna-Sofie; Sichlau, Rasmus; Egerod, Kristoffer L; Timshel, Pascal; Kowalski, Timothy J; Gribble, Fiona M; Reiman, Frank; Hansen, Harald S; Howard, Andrew D; Holst, Birgitte; Schwartz, Thue W.

    In: Endocrinology, Vol. 157, No. 12, en20161334, 25.10.2016, p. 4561-4569.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population. / Vestmar, Marie A; Galijatovic, Ehm Astrid Andersson; Christensen, Charlotte Riis; Pedersen, Maria Hauge; Glümer, Charlotte; Linneberg, Allan; Witte, Daniel R; Jørgensen, Marit E; Christensen, Cramer; Brandslund, Ivan; Lauritzen, Torsten ; Pedersen, Oluf; Holst, Birgitte; Grarup, Niels; Schwartz, Thue W; Hansen, Torben.

    In: Journal of Medical Genetics, Vol. 53, No. 9, 09.2016, p. 616-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors. / Engelstoft, M S; Schwartz, T W.

    In: Trends in Endocrinology and Metabolism, Vol. 27, No. 9, 09.2016, p. 665-675.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119. / Hassing, Helle A; Fares, Suzan; Larsen, Olav; Pad, Hamideh; Pedersen, Maria Hauge; Jones, Robert M; Schwartz, Thue W; Hansen, Harald S; Rosenkilde, Mette M.

    In: Biochemical Pharmacology, Vol. 119, No. 1, 26.08.2016, p. 66-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

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