Thue W. Schwartz

Thue W. Schwartz

Professor

  • NNF Center for Basic Metabolic Research

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85


  1. 2019
  2. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. / Lückmann, Michael; Trauelsen, Mette; Bentsen, Marie A; Nissen, Tinne A D; Martins, Joao; Fallah, Zohreh; Nygaard, Mads M; Papaleo, Elena; Lindorff-Larsen, Kresten; Schwartz, Thue W; Frimurer, Thomas M.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 14, 02.04.2019, p. 7123-7128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity. / Arora, Tulika; Rudenko, Olga; Egerod, Kristoffer Lihme; Husted, Anna Sofie; Kovatcheva-Datchary, Petia; Akrami, Rozita; Kristensen, Mette; Schwartz, Thue W.; Backhed, Fredrik.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 316, No. 3, 03.2019, p. E453-E463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. / Chen, Shuanghong; Lu, Mengjie; Liu, Dongsheng; Yang, Lingyun; Yi, Cuiying; Ma, Limin; Zhang, Hui; Liu, Qing; Frimurer, Thomas M.; Wang, Ming-Wei; Schwartz, Thue W.; Stevens, Raymond C.; Wu, Beili; Wuthrich, Kurt; Zhao, Qiang.

    In: Nature Communications, Vol. 10, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. / Riis, Simon; Christensen, Britt; Nellemann, Birgitte; Moller, Andreas Ruch; Husted, Anna Sofie; Pedersen, Steen B.; Schwartz, Thue W.; Jorgensen, Jens Otto Lunde; Jessen, Niels.

    In: Journal of Applied Physiology, Vol. 126, No. 3, 2019, p. 569-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Preassociation between the 5-HT7 serotonin receptor and G protein G(s): molecular determinants and association with low potency activation of adenylyl cyclase. / Ulsund, Andrea Hembre; Dahl, Marie; Frimurer, Thomas M.; Manfra, Ornella; Schwartz, Thue W.; Levy, Finn Olav; Andressen, Kjetil Wessel.

    In: FASEB Journal, Vol. 33, No. 3, 2019, p. 3870-3886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. / Rudenko, Olga; Shang, Jin; Munk, Alexander; Ekberg, Jeppe P.; Petersen, Natalia; Engelstoft, Maja S; Egerod, Kristoffer L; Hjorth, Siv A; Wu, Margaret; Feng, Yue; Zhou, Yun-Ping; Mokrosinski, Jacek; Thams, Peter; Reimann, Frank; Gribble, Fiona; Rehfeld, Jens F; Holst, Jens J.; Treebak, Jonas T.; Howard, Andrew D; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 19, 2019, p. 49-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa. / Tough, Iain R; Forbes, Sarah; Herzog, Herbert; Jones, Robert M; Schwartz, Thue W; Cox, Helen M.

    In: Endocrinology, Vol. 159, No. 4, 19.02.2018, p. 1704-1717.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. / Lund, Mari L; Egerod, Kristoffer L; Engelstoft, Maja S; Dmytriyeva, Oksana; Theodorsson, Elvar; Patel, Bhavik A; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 11, 2018, p. 70-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published
  12. Published

    Microbial regulation of the L cell transcriptome. / Arora, Tulika; Akrami, Rozita; Pais, Ramona; Bergqvist, Linda; Johansson, Bengt R; Schwartz, Thue W.; Reimann, Frank; Gribble, Fiona M; Bäckhed, Fredrik.

    In: Scientific Reports, Vol. 8, 1207, 2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. / Egerod, Kristoffer L.; Petersen, Natalia; Timshel, Pascal N.; Rekling, Jens C.; Wang, Yibing; Liu, Qinghua; Schwartz, Thue W.; Gautron, Laurent.

    In: Molecular Metabolism, Vol. 12, 2018, p. 62-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1. / Rexen Ulven, Elisabeth; Trauelsen, Mette; Brvar, Matjaz; Lückmann, Michael; Bielefeldt, Line Ø; Jensen, Lisa K I; Schwartz, Thue W; Frimurer, Thomas M.

    In: Scientific Reports, Vol. 8, No. 1, 10010, 2018, p. 1-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The HETE Is on FFAR1 and Pancreatic Islet Cells. / Trauelsen, Mette; Lückmann, Michael; Frimurer, Thomas M; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 27, No. 2, 2018, p. 273-275.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2017
  17. Published

    Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91. / Trauelsen, Mette; Rexen Ulven, Elisabeth; Hjorth, Siv A; Brvar, Matjaz; Monaco, Claudia; Frimurer, Thomas M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 6, No. 12, 12.2017, p. 1585-1596.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Gq and Gs signaling acting in synergy to control GLP-1 secretion. / Pedersen, Maria Hauge; Ekberg, Jeppe Hvidtfeldt; Engelstoft, Maja Storm; Timshel, Pascal; Madsen, Andreas N; Schwartz, Thue W.

    In: Molecular and Cellular Endocrinology, Vol. 449, 07.2017, p. 64-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    GPCR-Mediated Signaling of Metabolites. / Husted, Anna Sofie; Trauelsen, Mette; Rudenko, Olga; Hjorth, Siv A; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 25, No. 4, 04.04.2017, p. 777-796.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies. / Niss Arfelt, Kristine; Barington, Line; Benned-Jensen, Tau; Kubale, Valentina; Kovalchuk, Alexander L; Daugvilaite, Viktorija; Pravsgaard Christensen, Jan; Randrup Thomsen, Allan; Egerod, Kristoffer L; Bassi, Maria R; Spiess, Katja; Schwartz, Thue W; Wang, Hongsheng; Morse, Herbert C; Holst, Peter J; Rosenkilde, Mette M.

    In: Blood, Vol. 129, No. 7, 2017, p. 866-878.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. / Frimurer, Thomas M.; Mende, Franziska; Graae, Anne-Sofie; Engelstoft, Maja S.; Egerod, Kristoffer L.; Nygaard, Rie; Gerlach, Lars-Ole; Hansen, Jakob Bondo; Schwartz, Thue W.; Holst, Birgitte.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 3, 2017, p. 886-898.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural biology: Full monty of family B GPCRs. / Schwartz, Thue W; Frimurer, Thomas M.

    In: Nature Chemical Biology, Vol. 13, No. 8, 2017, p. 819-821.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action. / Lückmann, Michael; Amarandi, Roxana-Maria; Papargyri, Natalia; Jakobsen, Mette H; Christiansen, Elisabeth; Jensen, Lars Juhl; Pui, Aurel; Schwartz, Thue W.; Rosenkilde, Mette Marie; Frimurer, Thomas Michael.

    In: Chemical Biology & Drug Design, Vol. 89, No. 3, 2017, p. 289–296.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2016
  25. Published

    High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice. / Thieme, V; Jolly, N; Madsen, A N; Bellmann-Sickert, K; Schwartz, T W; Holst, B; Cox, H M; Beck-Sickinger, A G.

    In: British Journal of Pharmacology, Vol. 173, No. 22, 11.2016, p. 3208-3221.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40). / Ekberg, Jeppe H; Pedersen, Maria Hauge; Kristensen, Line V; Madsen, Andreas N; Engelstoft, Maja S; Husted, Anna-Sofie; Sichlau, Rasmus; Egerod, Kristoffer L; Timshel, Pascal; Kowalski, Timothy J; Gribble, Fiona M; Reiman, Frank; Hansen, Harald S; Howard, Andrew D; Holst, Birgitte; Schwartz, Thue W.

    In: Endocrinology, Vol. 157, No. 12, en20161334, 25.10.2016, p. 4561-4569.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population. / Vestmar, Marie A; Galijatovic, Ehm Astrid Andersson; Christensen, Charlotte Riis; Pedersen, Maria Hauge; Glümer, Charlotte; Linneberg, Allan; Witte, Daniel R; Jørgensen, Marit E; Christensen, Cramer; Brandslund, Ivan; Lauritzen, Torsten ; Pedersen, Oluf; Holst, Birgitte; Grarup, Niels; Schwartz, Thue W; Hansen, Torben.

    In: Journal of Medical Genetics, Vol. 53, No. 9, 09.2016, p. 616-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors. / Engelstoft, M S; Schwartz, T W.

    In: Trends in Endocrinology and Metabolism, Vol. 27, No. 9, 09.2016, p. 665-675.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119. / Hassing, Helle A; Fares, Suzan; Larsen, Olav; Pad, Hamideh; Pedersen, Maria Hauge; Jones, Robert M; Schwartz, Thue W; Hansen, Harald S; Rosenkilde, Mette M.

    In: Biochemical Pharmacology, Vol. 119, No. 1, 26.08.2016, p. 66-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. / Cornelia Peeters, Miriam; Mos, Iris; Lenselink, Eelke B; Lucchesi, Martina; IJzerman, Adriaan P; Schwartz, Thue W.

    In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, No. 5, 05.2016, p. 1836-1848.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism. / Grunddal, Kaare Villum; Ratner, Cecilia F; Svendsen, Berit; Sommer, Felix; Engelstoft, Maja S; Madsen, Andreas N; Pedersen, Jens; Nøhr, Mark K; Egerod, Kristoffer L; Nawrocki, Andrea R; Kowalski, Timothy; Howard, Andrew D; Poulsen, Steen Seier; Offermanns, Stefan; Bäckhed, Gert Fredrik; Holst, Jens J; Holst, Birgitte; Schwartz, Thue W.

    In: Endocrinology, Vol. 157, No. 1, en20151600, 01.2016, p. 176-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. / Svendsen, Berit; Pais, Ramona; Engelstoft, Maja S; Milev, Nikolay B; Richards, Paul; Christiansen, Charlotte B; Egerod, Kristoffer L; Jensen, Signe Marie; Habib, Abdella M; Gribble, Fiona M; Schwartz, Thue W; Reimann, Frank; Holst, Jens J.

    In: Journal of Endocrinology, Vol. 228, No. 1, 2016, p. 39-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published
  34. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor. / Hassing, H A; Engelstoft, M S; Sichlau, R M; Madsen, A N; Rehfeld, J F; Pedersen, J; Jones, R M; Holst, J J; Schwartz, T W; Rosenkilde, M M; Hansen, Harald S.

    In: BioFactors, Vol. 42, No. 6, 2016, p. 665-673.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2015
  36. Published

    The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration. / Cornelia Peeters, Miriam; Fokkelman, Michiel; Boogaard, Bob; Egerod, Kristoffer L; van de Water, Bob; IJzerman, Ad P; Schwartz, Thue W.

    In: Cellular Signalling, Vol. 27, No. 12, 12.2015, p. 2579-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics. / Park, Minyoung; Sivertsen, Bjørn Behrens; Els-Heindl, Sylvia; Huber, Thomas; Holst, Birgitte; Beck-Sickinger, Annette G.; Schwartz, Thue W.; Sakmar, Thomas P.

    In: Chemistry & Biology, Vol. 22, No. 11, 19.11.2015, p. 1431-1436.

    Research output: Contribution to journalLetterResearchpeer-review

  38. Published

    Research Resource : A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells. / Engelstoft, Maja S; Lund, Mari L; Grunddal, Kaare V; Egerod, Kristoffer L; Osborne-Lawrence, Sherri; Poulsen, Steen Seier; Zigman, Jeffrey M; Schwartz, Thue W.

    In: Molecular endocrinology (Baltimore, Md.), Vol. 29, No. 11, 11.2015, p. 1658-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The MicroRNA Repertoire in Enteroendocrine Cells : Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage. / Knudsen, Lina A; Petersen, Natalia; Schwartz, Thue W; Egerod, Kristoffer L.

    In: Endocrinology, Vol. 156, No. 11, 11.2015, p. 3971-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells. / Egerod, Kristoffer L; Engelstoft, Maja S; Lund, Mari L; Grunddal, Kaare V; Zhao, Mirabella; Barir-Jensen, Dominique; Nygaard, Eva B; Petersen, Natalia; Holst, Jens J; Schwartz, Thue W.

    In: Endocrinology, Vol. 156, No. 11, 11.2015, p. 3909-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network. / Valentin-Hansen, Louise; Frimurer, Thomas M; Mokrosinski, Jacek; Holliday, Nicholas D; Schwartz, Thue W.

    In: The Journal of Biological Chemistry, Vol. 290, No. 40, 02.10.2015, p. 24495-508.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. / Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W.; Levy, Finn Olav; Andressen, Kjetil Wessel.

    In: A C S Chemical Neuroscience, Vol. 6, No. 7, 07.2015, p. 1206–1218.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Ghrelin. / Mueller, T. D.; Nogueiras, R.; Andermann, M. L.; Andrews, Z. B.; Anker, S. D.; Argente, J.; Batterham, R. L.; Benoit, S. C.; Bowers, C. Y.; Broglio, F.; Casanueva, F. F.; D'Alessio, D.; Depoortere, I.; Geliebter, A.; Ghigo, E.; Cole, P. A.; Cowley, M.; Cummings, D. E.; Dagher, A.; Diano, S.; Dickson, S. L.; Dieguez, C.; Granata, R.; Grill, H. J.; Grove, K.; Habegger, K. M.; Heppner, K.; Heiman, M. L.; Holsen, L.; Holst, B.; Inui, A.; Jansson, J. O.; Kirchner, H.; Korbonits, M.; Laferrere, B.; LeRoux, C. W.; Lopez, M.; Morin, S.; Nakazato, M.; Nass, R.; Perez-Tilve, D.; Pfluger, P. T.; Schwartz, T. W.; Seeley, R. J.; Sleeman, M.; Sun, Y.; Sussel, L.; Tong, J.; Thorner, M. O.; van der Lely, A. J.; van der Ploeg, L. H. T.; Zigman, J. M.; Kojima, M.; Kangawa, K.; Smith, R. G.; Horvath, T.; Tschoep, M. H.

    In: Molecular Metabolism, Vol. 4, No. 6, 06.2015, p. 437-460.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia. / Nøhr, Mark Klitgaard; Egerod, K L; Christiansen, S H; Gille, A; Offermanns, S; Schwartz, Thue W.; Møller, M.

    In: Neuroscience, Vol. 290, 02.04.2015, p. 126-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system : new aspects on Alzheimer's disease. / Ádori, Csaba; Glück, Laura; Barde, Swapnali; Yoshitake, Takashi; Kovacs, Gabor G; Mulder, Jan; Maglóczky, Zsófia; Havas, László; Bölcskei, Kata; Mitsios, Nicholas; Uhlén, Mathias; Szolcsányi, János; Kehr, Jan; Rönnbäck, Annica; Schwartz, Thue; Rehfeld, Jens F; Harkany, Tibor; Palkovits, Miklós; Schulz, Stefan; Hökfelt, Tomas.

    In: Acta Neuropathologica, Vol. 129, No. 4, 04.2015, p. 541-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. / Hamann, Jörg; Aust, Gabriela; Araç, Demet; Engel, Felix B; Formstone, Caroline; Fredriksson, Robert; Hall, Randy A; Harty, Breanne L; Kirchhoff, Christiane; Knapp, Barbara; Krishnan, Arunkumar; Liebscher, Ines; Lin, Hsi-Hsien; Martinelli, David C; Monk, Kelly R; Cornelia Peeters, Miriam; Piao, Xianhua; Prömel, Simone; Schöneberg, Torsten; Schwartz, Thue W; Singer, Kathleen; Stacey, Martin; Ushkaryov, Yuri A; Vallon, Mario; Wolfrum, Uwe; Wright, Mathew W; Xu, Lei; Langenhan, Tobias; Schiöth, Helgi B.

    In: Pharmacological Reviews, Vol. 67, No. 2, 04.2015, p. 338-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo. / Pedersen, Maria Hauge; Bentsen, Marie Aare; Husted, Anna S; Ekberg, Jeppe P; Wright, Michael J; Di Salvo, Jerry; Weinglass, Adam B; Engelstoft, Maja Storm; Madsen, Andreas N; Lückmann, Michael; Miller, Michael W; Trujillo, Maria E; Frimurer, Thomas M; Holst, Birgitte; Howard, Andrew D; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 4, No. 1, 01.2015, p. 3-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening. / Norn, Christoffer; Pedersen, Maria Hauge; Engelstoft, Maja S.; Kim, Sun Hee; Lehmann, Juerg; Jones, Robert M.; Schwartz, Thue W.; Frimurer, Thomas M.

    In: Structure, Vol. 23, No. 12, 2015, p. 2377-2386.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2014
  50. Published

    The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. / Panaro, Brandon L; Tough, Iain R; Engelstoft, Maja S; Matthews, Robert T; Digby, Gregory J; Møller, Cathrine L; Svendsen, Berit; Gribble, Fiona; Reimann, Frank; Holst, Jens Juul; Holst, Birgitte; Schwartz, Thue W; Cox, Helen M; Cone, Roger D.

    In: Cell Metabolism, Vol. 20, No. 6, 02.12.2014, p. 1018-29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. / Engelstoft, Maja Storm; Norn, C; Pedersen, Maria Hauge; Holliday, N D; Elster, L; Lehmann, J; Jones, R M; Frimurer, T M; Schwartz, T W.

    In: British Journal of Pharmacology, Vol. 171, No. 24, 12.2014, p. 5774-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. / Tian, He; Naganathan, Saranga; Kazmi, Manija A; Schwartz, Thue W.; Sakmar, Thomas P; Huber, Thomas.

    In: ChemBioChem, Vol. 15, No. 12, 18.08.2014, p. 1820-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid. / Valentin-Hansen, Louise; Park, Minyoung; Huber, Thomas; Grunbeck, Amy; Naganathan, Saranga; Schwartz, Thue W.; Sakmar, Thomas P.

    In: The Journal of Biological Chemistry, Vol. 289, No. 26, 27.06.2014, p. 18045-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure and appetite in overweight men. / Schmidt, Julie Berg; Gregersen, Nikolaj Ture; Pedersen, Sue D; Arentoft, Johanne L; Ritz, Christian; Schwartz, Thue W.; Holst, Jens Juul; Astrup, Arne; Sjödin, Anders Mikael.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 306, No. 11, 2014, p. E1248-E1256.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2013
  56. Published

    Enteroendocrine cell types revisited. / Engelstoft, Maja S; Egerod, Kristoffer Lihme; Lund, Mari L; Schwartz, Thue W.

    In: Current Opinion in Pharmacology, Vol. 13, No. 6, 12.2013, p. 912-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. / Engelstoft, Maja S; Park, Won-Mee; Sakata, Ichiro; Kristensen, Line V; Husted, Anna Sofie; Osborne-Lawrence, Sherri; Piper, Paul K; Walker, Angela K; Pedersen, Maria H; Nøhr, Mark K; Pan, Jie; Sinz, Christopher J; Carrington, Paul E; Akiyama, Taro E; Jones, Robert M; Tang, Cong; Ahmed, Kashan; Offermanns, Stefan; Egerod, Kristoffer Lihme; Zigman, Jeffrey M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 2, No. 4, 11.2013, p. 376-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes. / Nøhr, Mark K; Pedersen, Maria H; Gille, Andreas; Egerod, Kristoffer Lihme; Engelstoft, Maja S; Husted, Anna Sofie; Sichlau, Rasmus M; Grunddal, Kaare V; Seier Poulsen, Steen; Han, Sangdon; Jones, Robert M; Offermanns, Stefan; Schwartz, Thue W.

    In: Endocrinology, 24.07.2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells. / Pedersen, J; Ugleholdt, R K; Jørgensen, S M; Windeløv, J A; Grunddal, K V; Schwartz, T W; Füchtbauer, Ernst-Martin; Poulsen, S S; Holst, P J; Holst, Jens Juul.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 304, No. 1, 01.01.2013, p. E60-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. / Albrechtsen, Anders; Grarup, Niels; Li, Y.; Sparsø, Thomas Hempel; Tian, G.; Cao, H.; Jiang, T.; Kim, S.Y.; Korneliussen, Thorfinn Sand; Li, Q.; Nie, C.; Wu, R.; Skotte, Line; Morris, A.P.; Ladenvall, C.; Cauchi, S.; Stancáková, A.; Andersen, G.; Astrup, Arne; Banasik, Karina; Bennett, A.J.; Bolund, Lars; Charpentier, G.; Chen, Y.; Dekker, J.M.; Doney, A.S.F.; Dorkhan, M.; Forsen, T.; Frayling, T.M.; Groves, C.J.; Gui, Y.; Hallmans, G.; Hattersley, A.T.; He, K.; Hitman, G.A.; Holmkvist, J.; Huang, S.; Jiang, H.; Jin, X.; Justesen, Johanne Marie; Kristiansen, Karsten; Kuusisto, J.; Lajer, M.; Lantieri, O.; Li, W.; Liang, H.; Liao, Q.; Liu, X.; Ma, T.; Ma, X.; Manijak, M.P.; Marre, M.; Mokrosinski, Jacek; Morris, A.D.; Mu, B.; Nielsen, A.A.; Nijpels, G.; Nilsson, P.; Palmer, C.N.A.; Rayner, N.W.; Renström, F.; Ribel-Madsen, Rasmus; Robertson, N.; Rolandsson, O.; Rossing, P.; Schwartz, Thue W.; Slagboom, P.E.; Sterner, M.; Tang, M.; Tarnow, L.; Tuomi, T.; Van't Riet, E.; van Leeuwen, N.; Varga, T.V.; Vestmar, Marie Aare; Walker, M.; Wang, B.; Wang, Y.; Wu, H.; Xi, F.; Yengo, L.; Yu, C.; Zhang, X.; Zhang, J.; Zhang, Q.; Zhang, W.; Zheng, H.; Zhou, Y.; Altshuler, D.; 't Hart, L.M.; Franks, P.W.; Balkau, B.; Froguel, P.; McCarthy, M.I.; Laakso, M.; Groop, L.; Christensen, C.; Brandslund, I.; Lauritzen, T.; Witte, D.R.; Linneberg, A.; Jørgensen, Torben; Hansen, Torben; Wang, Jun; Nielsen, Rasmus; Pedersen, Oluf.

    In: Diabetologia, Vol. 56, No. 2, 2013, p. 298-310.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95 : quantitative characterization of interactions. / Møller, Thor C; Wirth, Volker F; Roberts, Nina Ingerslev; Bender, Julia; Bach, Anders; Jacky, Birgitte P S; Strømgaard, Kristian; Deussing, Jan M; Schwartz, Thue W; Martinez, Karen L.

    In: PLOS ONE, Vol. 8, No. 5, e63352, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 2012
  63. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. / Valentin-Hansen, Louise; Holst, Birgitte; Frimurer, Thomas M; Schwartz, Thue W; Hansen, Louise Valentin.

    In: Journal of Biological Chemistry, Vol. 287, No. 52, 21.12.2012, p. 43516-43526.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin. / Egerod, Kristoffer L; Engelstoft, Maja S; Grunddal, Kaare V; Nøhr, Mark K; Secher, Anna; Sakata, Ichiro; Pedersen, Jens; Windeløv, Johanne A; Füchtbauer, Ernst-Martin; Olsen, Jørgen; Sundler, Frank; Christensen, Jan P; Wierup, Nils; Olsen, Jesper V; Holst, Jens J; Zigman, Jeffrey M; Poulsen, Steen S; Schwartz, Thue W.

    In: Endocrinology, Vol. 153, No. 12, 01.12.2012, p. 5782-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Dissecting signaling and functions of adhesion G protein-coupled receptors. / Araç, Demet; Aust, Gabriela; Calebiro, Davide; Engel, Felix B; Formstone, Caroline; Goffinet, André; Hamann, Jörg; Kittel, Robert J; Liebscher, Ines; Lin, Hsi-Hsien; Monk, Kelly R; Petrenko, Alexander; Piao, Xianhua; Prömel, Simone; Schiöth, Helgi B; Schwartz, Thue W.; Stacey, Martin; Ushkaryov, Yuri A; Wobus, Manja; Wolfrum, Uwe; Xu, Lei; Langenhan, Tobias.

    In: Annals of the New York Academy of Sciences, Vol. 1276, 12.2012, p. 1-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor. / Hansen, Louise Valentin; Groenen, Marleen; Nygaard, Rie; Frimurer, Thomas M; Holliday, Nicholas D; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 287, No. 38, 14.09.2012, p. 31973-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. / Els, Sylvia; Schild, Enrico; Petersen, Pia Steen; Kilian, Tom-Marten; Mokrosinski, Jacek; Frimurer, Thomas M; Chollet, Constance; Schwartz, Thue W; Holst, Birgitte; Beck-Sickinger, Annette G.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 17, 13.09.2012, p. 7437-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. / Mokrosinski, Jacek; Frimurer, Thomas M; Sivertsen, Bjoern; Schwartz, Thue W; Holst, Birgitte.

    In: Journal of Biological Chemistry, Vol. 287, 09.2012, p. 33488-33502.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects. / Schmidt, Julie Berg; Gregersen, Nikolaj Ture; Pedersen, Susie Dawn; Holst, Jens Juul; Schwartz, Thue W.; Astrup, Arne; Sjödin, Anders Mikael.

    In: Regulatory Peptides, Vol. 177, No. Supplement, 10.08.2012, p. S32.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  70. Published

    GPR119 as a fat sensor. / Hansen, Harald S; Rosenkilde, Mette M; Holst, Jens Juul; Schwartz, Thue W.

    In: Trends in Pharmacological Sciences, Vol. 33, No. 7, 07.2012, p. 374-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. 2011
  72. Published

    Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2 : IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST. / Benned-Jensen, Tau; Smethurst, Christopher; Holst, Peter Johannes; Page, Kevin R.; Sauls, Howard; Sivertsen, Bjørn Behrens; Schwartz, Thue W.; Blanchard, Andy; Jepras, Robert; Rosenkilde, Mette Marie.

    In: Journal of Biological Chemistry, Vol. 286, 19.08.2011, p. 29292-29302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. / Petersen, Pia Steen; Jin, Chunyu; Madsen, Andreas Nygaard; Rasmussen, Maria; Kuhre, Rune; Egerod, Kristoffer L; Nielsen, Lars Bo; Schwartz, Thue W; Holst, Birgitte.

    In: FASEB Journal, 22.07.2011, p. 3803-3814.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Unique interaction pattern for a functionally biased ghrelin receptor agonist. / Sivertsen, Bjørn Behrens; Lang, Manja; Frimurer, Thomas M.; Holliday, Nicholas D.; Bach, Anders; Els, Sylvia; Engelstoft, Maja Storm; Petersen, Pia Steen; Madsen, Andreas Nygaard; Schwartz, Thue W.; Beck-Sickinger, Annette G.; Holst, Birgitte.

    In: The Journal of Biological Chemistry, Vol. 286, No. 23, 10.06.2011, p. 20845-20860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    KU bestemmer selv over sin forskning. / Wewer, Ulla M.; Holst, Jens Juul; Schwartz, Thue W.; Quistorff, Bjørn.

    In: Universitetsavisen, 02.06.2011.

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  76. Published

    Reversible switching of ultrastrong light-molecule coupling. / Schwartz, T; Hutchison, J A; Genet, C; Ebbesen, T W.

    In: Physical Review - Index, Vol. 106, 13.05.2011, p. 196405.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    G protein-coupled receptor modulation with pepducins: moving closer to the clinic. / Dimond, Patricia; Carlson, Kenneth; Bouvier, Michel ; Gerard, Craig ; Xu, Lei; Covic, Lidija; Agarwal, Anika; Ernst, Oliver P.; Janz, Jay M.; Schwartz, Thue W.; Gardella, Thomas J.; Milligan, Graeme; Kuliopulos, Athan; Sakmar, Thomas P.; Hunt III, Stephen W.

    In: New York Academy of Sciences. Annals, Vol. 1226, 05.2011, p. 34-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    G protein-coupled receptor modulation with pepducins : moving closer to the clinic. / Dimond, Patricia; Carlson, Kenneth; Bouvier, Michel; Gerard, Craig; Xu, Lei; Covic, Lidija; Agarwal, Anika; Ernst, Oliver P; Janz, Jay M; Schwartz, Thue W.; Gardella, Thomas J; Milligan, Graeme; Kuliopulos, Athan; Sakmar, Thomas P; Hunt, Stephen W.

    In: Annals of the New York Academy of Sciences, Vol. 1226, 2011, p. 34-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. / Bellmann-Sickert, Kathrin; Elling, Christian E; Madsen, Andreas N; Little, Paul B; Lundgren, Karsten; Gerlach, Lars-Ole; Bergmann, Ralf; Holst, Birgitte; Schwartz, Thue W; Beck-Sickinger, Annette G.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 8, 2011, p. 2658-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    ß-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. / Egerod, Kristoffer Lihme; Jin, Chunyu; Petersen, Pia Steen; Wierup, Nils; Sundler, Frank; Holst, Birgitte; Schwartz, Thue W.

    In: International Journal of Endocrinology, Vol. 2011, 2011, p. 401258.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. 2010
  82. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. / Holst, Birgitte; Nygaard, Rie; Hansen, Louise Valentin; Bach, Anders; Engelstoft, Maja S; Petersen, Pia S; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 6, 2010, p. 3973-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    An enteroendocrine full package solution. / Schwartz, Thue W; Holst, Birgitte.

    In: Cell Metabolism, Vol. 11, No. 6, 2010, p. 445-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. / Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 25, 2010, p. 19625-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. / Gjesing, Anette P.; Larsen, Lesli Hingstrup; Torekov, Signe Sørensen; Hainerová, Irena Aldhoon; Kapur, Rahul; Johansen, Anders; Albrechtsen, Anders; Boj, Sylvia; Holst, Birgitte; Harper, Angela; Urhammer, Søren A.; Borch-Johnsen, Knut; Pisinger, Charlotta Holm; Echwald, Søren M; Eiberg, Hans Rudolf Lytchoff; Astrup, Arne; Lebl, Jan; Ferrer, Jorge; Schwartz, Thue W.; Hansen, Torben; Pedersen, Oluf.

    In: P L o S One, Vol. 5, No. 4, 2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. / Andersson, Ehm A; Holst, Birgitte; Sparsø, Thomas; Grarup, Niels; Banasik, Karina; Holmkvist, Johan; Jørgensen, Torben; Borch-Johnsen, Knut; Egerod, Kristoffer L; Lauritzen, Torsten; Sørensen, Thorkild I A; Bonnefond, Amélie; Meyre, David; Froguel, Philippe; Schwartz, Thue W; Pedersen, Oluf; Hansen, Torben.

    In: Diabetes, Vol. 59, No. 6, 2010, p. 1539-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII. / Gbahou, F; Holst, B; Schwartz, T W.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 1, 2010, p. 51-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. / Li, Yingrui; Vinckenbosch, Nicolas; Tian, Geng; Huerta-Sanchez, Emilia; Jiang, Tao; Jiang, Hui; Albrechtsen, Anders; Andersen, Gitte; Cao, Hongzhi; Korneliussen, Thorfinn Sand; Grarup, Niels; Guo, Yiran; Hellman, Ines; Jin, Xin; Li, Qibin; Liu, Jiangtao; Liu, Xiao; Sparsø, Thomas; Tang, Meifang; Wu, Honglong; Wu, Renhua; Yu, Chang; Zheng, Hancheng; Astrup, Arne; Bolund, Lars; Holmkvist, Johan; Jørgensen, Torben; Kristiansen, Karsten; Schmitz, Ole; Schwartz, Thue W; Zhang, Xiuqing; Li, Ruiqiang; Yang, Huanming; Wang, Jian; Hansen, Torben; Pedersen, Oluf; Nielsen, Rasmus; Wang, Jun.

    In: Nature Genetics, Vol. 42, No. 11, 2010, p. 969-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Targeting CXCR4 in HIV Cell-Entry Inhibition. / Steen, Anne; Schwartz, T W; Rosenkilde, M M.

    In: Mini reviews in medicinal chemistry, Vol. 9, No. 14, 2010, p. 1605-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    The minor binding pocket: a major player in 7TM receptor activation. / Rosenkilde, Mette Marie; Benned-Jensen, Tau; Frimurer, Thomas M.; Schwartz, Thue W.

    In: Trends in Pharmacological Sciences, Vol. 31, No. 12, 2010, p. 567-574.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. 2009
  92. Published

    Construction of covalently coupled, concatameric dimers of 7TM receptors. / Terpager, Marie; Scholl, D Jason; Kubale, Valentina; Martini, Lene; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Receptors and Signal Transduction, Vol. 29, No. 5, 2009, p. 235-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. / Holst, Birgitte; Egerod, Kristoffer L; Jin, Chunyu; Petersen, Pia Steen; Østergaard, Mette Viberg; Hald, Jacob; Sprinkel, A M Ejernaes; Størling, Joachim; Mandrup-Poulsen, Thomas; Holst, Jens J; Thams, Peter; Orskov, Cathrine; Wierup, Nils; Sundler, Frank; Madsen, Ole D; Schwartz, Thue W.

    In: Endocrinology, Vol. 150, No. 6, 2009, p. 2577-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Ligand binding and micro-switches in 7TM receptor structures. / Nygaard, Rie; Frimurer, Thomas M; Holst, Birgitte; Rosenkilde, Mette M; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 30, No. 5, 2009, p. 249-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    [Fine needle aspiration cytology of mammography screening]. / Engvad, B.; Laenkholm, A.V.; Schwartz, Thue W.; Bak, M.

    In: Ugeskrift for læger, Vol. 171, No. 34, 2009, p. 2379-2382.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. 2008
  97. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 17.06.2008, p. 23121-23128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    A gut feeling for obesity: 7TM sensors on enteroendocrine cells. / Engelstoft, Maja Storm; Egerod, Kristoffer L; Holst, Birgitte; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 8, No. 6, 2008, p. 447-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: Biochemistry, Vol. 47, No. 35, 2008, p. 9198-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET. / Joergensen, R.; Holliday, N.D.; Hansen, J.L.; Vrecl, M.; Heding, A.; Elling, C.E.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, Vol. 73, No. 2, 2008, p. 349-358.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: FEBS Letters, Vol. 582, No. 17, 2008, p. 2583-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. / Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 75, No. 1, 2008, p. 44-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 2008, p. 23121-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Structural biology: A moving story of receptors. / Schwartz, Thue W; Hubbell, Wayne L.

    In: Nature, Vol. 455, No. 7212, 2008, p. 473-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. 2007
  106. Published

    Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? / Schwartz, Thue W; Holst, Birgitte.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 28, No. 8, 2007, p. 366-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. / Jorgensen, Rasmus; Holliday, Nicholas D; Hansen, Jakob L; Vrecl, Milka; Heding, Anders; Schwartz, Thue W; Elling, Christian E.

    In: Molecular Pharmacology, Vol. 73, No. 2, 2007, p. 349-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. / Egerod, Kristoffer L; Holst, Birgitte; Petersen, Pia S; Hansen, Jacob B; Mulder, Jan; Hökfelt, Tomas; Schwartz, Thue W.

    In: Molecular Endocrinology, Vol. 21, No. 7, 2007, p. 1685-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. / Holst, Birgitte; Mokrosinski, Jacek; Lang, Manja; Brandt, Erik; Nygaard, Rie; Frimurer, Thomas M; Beck-Sickinger, Annette G; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 282, No. 21, 2007, p. 15799-811.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. / Holliday, Nicholas D; Holst, Birgitte; Rodionova, Elena A; Schwartz, Thue W; Cox, Helen M.

    In: Molecular Endocrinology, Vol. 21, No. 12, 2007, p. 3100-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  111. Published

    Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. / Lüttichau, Hans R; Johnsen, Anders H; Jurlander, Jesper; Rosenkilde, Mette M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 282, No. 24, 2007, p. 17794-805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  112. Published

    Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. / Hatse, Sigrid; Huskens, Dana; Princen, Katrien; Vermeire, Kurt; Bridger, Gary J; De Clercq, Erik; Rosenkilde, Mette M; Schwartz, Thue W; Schols, Dominique.

    In: Journal of Virology, Vol. 81, No. 7, 2007, p. 3632-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  113. Published

    Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. / Jensen, Pia C; Nygaard, Rie; Thiele, Stefanie; Elder, Amy; Zhu, Guoming; Kolbeck, Roland; Ghosh, Shomir; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Molecular Pharmacology, Vol. 72, No. 2, 2007, p. 327-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

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