Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. Published

    MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. / Lüttichau, H R; Gerstoft, J; Schwartz, T W.

    In: Journal of Leukocyte Biology, Vol. 70, No. 2, 2001, p. 277-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. / Andersson, Ehm A; Holst, Birgitte; Sparsø, Thomas; Grarup, Niels; Banasik, Karina; Holmkvist, Johan; Jørgensen, Torben; Borch-Johnsen, Knut; Egerod, Kristoffer L; Lauritzen, Torsten; Sørensen, Thorkild I A; Bonnefond, Amélie; Meyre, David; Froguel, Philippe; Schwartz, Thue W; Pedersen, Oluf; Hansen, Torben.

    In: Diabetes, Vol. 59, No. 6, 2010, p. 1539-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid. / Valentin-Hansen, Louise; Park, Minyoung; Huber, Thomas; Grunbeck, Amy; Naganathan, Saranga; Schwartz, Thue W.; Sakmar, Thomas P.

    In: The Journal of Biological Chemistry, Vol. 289, No. 26, 27.06.2014, p. 18045-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. / Gerlach, Lars Ole; Jakobsen, Janus S; Jensen, Kasper P; Rosenkilde, Mette R; Skerlj, Renato T; Ryde, Ulf; Bridger, Gary J; Schwartz, Thue W.

    In: Biochemistry, Vol. 42, No. 3, 2003, p. 710-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. / Elling, Christian E; Frimurer, Thomas M; Gerlach, Lars-Ole; Jorgensen, Rasmus; Holst, Birgitte; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 281, No. 25, 2006, p. 17337-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. / Holst, Birgitte; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 277, No. 49, 2002, p. 47662-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, No. 814, 1997, p. 142-151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity. / Arora, Tulika; Rudenko, Olga; Egerod, Kristoffer Lihme; Husted, Anna Sofie; Kovatcheva-Datchary, Petia; Akrami, Rozita; Kristensen, Mette; Schwartz, Thue W.; Backhed, Fredrik.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 316, No. 3, 03.2019, p. E453-E463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Microbial regulation of the L cell transcriptome. / Arora, Tulika; Akrami, Rozita; Pais, Ramona; Bergqvist, Linda; Johansson, Bengt R; Schwartz, Thue W.; Reimann, Frank; Gribble, Fiona M; Bäckhed, Fredrik.

    In: Scientific Reports, Vol. 8, 1207, 2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. / Frimurer, Thomas M.; Mende, Franziska; Graae, Anne-Sofie; Engelstoft, Maja S.; Egerod, Kristoffer L.; Nygaard, Rie; Gerlach, Lars-Ole; Hansen, Jakob Bondo; Schwartz, Thue W.; Holst, Birgitte.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 3, 2017, p. 886-898.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. / Hatse, Sigrid; Huskens, Dana; Princen, Katrien; Vermeire, Kurt; Bridger, Gary J; De Clercq, Erik; Rosenkilde, Mette M; Schwartz, Thue W; Schols, Dominique.

    In: Journal of Virology, Vol. 81, No. 7, 2007, p. 3632-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. / Mokrosinski, Jacek; Frimurer, Thomas M; Sivertsen, Bjoern; Schwartz, Thue W; Holst, Birgitte.

    In: Journal of Biological Chemistry, Vol. 287, 09.2012, p. 33488-33502.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. / Riis, Simon; Christensen, Britt; Nellemann, Birgitte; Moller, Andreas Ruch; Husted, Anna Sofie; Pedersen, Steen B.; Schwartz, Thue W.; Jorgensen, Jens Otto Lunde; Jessen, Niels.

    In: Journal of Applied Physiology, Vol. 126, No. 3, 2019, p. 569-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII. / Gbahou, F; Holst, B; Schwartz, T W.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 1, 2010, p. 51-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine. / Mizoue, L S; Sullivan, S K; King, D S; Kledal, T N; Schwartz, T W; Bacon, K B; Handel, T M.

    In: Journal of Biological Chemistry, Vol. 276, No. 36, 2001, p. 33906-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. / Lückmann, Michael; Trauelsen, Mette; Bentsen, Marie A; Nissen, Tinne A D; Martins, Joao; Fallah, Zohreh; Nygaard, Mads M; Papaleo, Elena; Lindorff-Larsen, Kresten; Schwartz, Thue W; Frimurer, Thomas M.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 14, 02.04.2019, p. 7123-7128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. / Jensen, Pia C; Nygaard, Rie; Thiele, Stefanie; Elder, Amy; Zhu, Guoming; Kolbeck, Roland; Ghosh, Shomir; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Molecular Pharmacology, Vol. 72, No. 2, 2007, p. 327-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. / Gerlach, Lars-Ole; Skerlj, R.T.; Bridger, G.J.; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. 276 (17), 2001, p. 14153-14160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular mechanism of 7TM receptor activation--a global toggle switch model. / Schwartz, Thue W; Frimurer, Thomas M; Holst, Birgitte; Rosenkilde, Mette M; Elling, Christian E.

    In: Annual Review of Pharmacology and Toxicology, Vol. 46, 2006, p. 481-519.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. / Rosenkilde, Mette M; Gerlach, Lars-Ole; Jakobsen, Janus S; Skerlj, Renato T; Bridger, Gary J; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 279, No. 4, 2004, p. 3033-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. / Rosenkilde, Mette Marie; Gerlach, Lars-Ole; Jakobsen, J.S.; Skerlj, R.T.; Bridger, Gary; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. VOl. 279, no. 4, 2004, p. 3033-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: FEBS Letters, Vol. 582, No. 17, 2008, p. 2583-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. / Rosenkilde, Mette M; Gerlach, Lars-Ole; Hatse, Sigrid; Skerlj, Renato T; Schols, Dominique; Bridger, Gary J; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 282, No. 37, 2007, p. 27354-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. / Holst, Birgitte; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, Vol. 994, 2003, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. / Rosenkilde, Mette M; Benned-Jensen, Tau; Holst, Peter J; Kledal, Thomas N; Lüttichau, Hans R; Larsen, Jørgen K; Christensen, Jan P; Schwartz, Thue W; Andersen, Helene.

    In: Journal of Biological Chemistry, Vol. 281, No. 19, 2006, p. 13199-208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Molecular structure and function of 7TM/G-protein coupled receptors. / Schwartz, Thue W.; Holst, Birgitte.

    Textbook of receptor Pharmacology. 2002. p. 65-84.

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  27. Published

    Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. / Waldhoer, Maria; Kledal, Thomas N; Farrell, Helen; Schwartz, Thue W.

    In: Journal of Virology, Vol. 76, No. 16, 2002, p. 8161-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S.; Princen, K.; Gerlach, Lars-Ole; Bridger, G.; Henson, G.; De Clercq, E.; Schwartz, Thue W.; Schols, D.

    In: Molecular Pharmacology, No. 60 (1), 2001, p. 164-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S; Princen, K; Gerlach, L O; Bridger, G; Henson, G; De Clercq, E; Schwartz, T W; Schols, D.

    In: Molecular Pharmacology, Vol. 60, No. 1, 2001, p. 164-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening. / Norn, Christoffer; Pedersen, Maria Hauge; Engelstoft, Maja S.; Kim, Sun Hee; Lehmann, Juerg; Jones, Robert M.; Schwartz, Thue W.; Frimurer, Thomas M.

    In: Structure, Vol. 23, No. 12, 2015, p. 2377-2386.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor. / Costa-Neto, C.M.; Miyakawa, A.A.; Oliveira, L.; Hjorth, Siv A.; Schwartz, Thue W.; Paiva, A.C.

    In: British Journal of Pharmacology, No. 130, no. 6, 2000, p. 1263-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. / Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 41, 1998, p. 4911-4914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. / Hatse, Sigrid; Princen, Katrien; Vermeire, Kurt; Gerlach, Lars-Ole; Rosenkilde, Mette M; Schwartz, Thue W; Bridger, Gary; De Clercq, Erik; Schols, Dominique.

    In: FEBS Letters, Vol. 546, No. 2-3, 2003, p. 300-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. / Martini, Lene; Hastrup, Hanne; Holst, Birgitte; Fraile-Ramos, Alberto; Marsh, Mark; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 62, No. 1, 2002, p. 30-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor. / Rosenkilde, M M; Lucibello, M; Holst, B; Schwartz, T W.

    In: FEBS Letters, Vol. 439, No. 1-2, 1998, p. 35-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism. / Grunddal, Kaare Villum; Ratner, Cecilia F; Svendsen, Berit; Sommer, Felix; Engelstoft, Maja S; Madsen, Andreas N; Pedersen, Jens; Nøhr, Mark K; Egerod, Kristoffer L; Nawrocki, Andrea R; Kowalski, Timothy; Howard, Andrew D; Poulsen, Steen Seier; Offermanns, Stefan; Bäckhed, Gert Fredrik; Holst, Jens J; Holst, Birgitte; Schwartz, Thue W.

    In: Endocrinology, Vol. 157, No. 1, en20151600, 01.2016, p. 176-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. / Holst, Birgitte; Brandt, Erik; Bach, Anders; Heding, Anders; Schwartz, Thue W.

    In: Molecular Endocrinology, Vol. 19, No. 9, 2005, p. 2400-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor. / Heding, A; Elling, C E; Schwartz, T W.

    In: Journal of Receptors and Signal Transduction, Vol. 22, No. 1-4, 2002, p. 241-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors. / Engelstoft, M S; Schwartz, T W.

    In: Trends in Endocrinology and Metabolism, Vol. 27, No. 9, 09.2016, p. 665-675.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor. / Hassing, H A; Engelstoft, M S; Sichlau, R M; Madsen, A N; Rehfeld, J F; Pedersen, J; Jones, R M; Holst, J J; Schwartz, T W; Rosenkilde, M M; Hansen, Harald S.

    In: BioFactors, Vol. 42, No. 6, 2016, p. 665-673.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. / Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 75, No. 1, 2008, p. 44-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s). / Jorgensen, Rasmus; Kubale, Valentina; Vrecl, Milka; Schwartz, Thue W; Elling, Christian E.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 322, No. 1, 2007, p. 148-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95 : quantitative characterization of interactions. / Møller, Thor C; Wirth, Volker F; Roberts, Nina Ingerslev; Bender, Julia; Bach, Anders; Jacky, Birgitte P S; Strømgaard, Kristian; Deussing, Jan M; Schwartz, Thue W; Martinez, Karen L.

    In: PLOS ONE, Vol. 8, No. 5, e63352, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. E-pub ahead of print

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. / Jepsen, Sara L.; Grunddal, Kaare V.; Wewer Albrechtsen, Nicolai J; Engelstoft, Maja S; Gabe, Maria B N; Jensen, Elisa P; Ørskov, Cathrine; Poulsen, Steen S; Rosenkilde, Mette M; Pedersen, Jens; Gribble, Fiona M; Reimann, Frank; Deacon, Carolyn F; Schwartz, Thue W; Christ, Andreas D; Martin, Rainer E; Holst, Jens J.

    In: A J P: Endocrinology and Metabolism (Online), 10.09.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor. / Holst, B; Elling, C E; Schwartz, T W.

    In: Molecular Pharmacology, Vol. 58, No. 2, 2000, p. 263-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. / Valentin-Hansen, Louise; Holst, Birgitte; Frimurer, Thomas M; Schwartz, Thue W; Hansen, Louise Valentin.

    In: Journal of Biological Chemistry, Vol. 287, No. 52, 21.12.2012, p. 43516-43526.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4. / Signoret, N.; Oldridge, J.; Pelchen-Matthews, A.; Klasse, P.J.; Tran, T.; Brass, L.F.; Rosenkilde, Mette Marie; Schwartz, Thue W.; Luther, Michael A.; Wells, T.N.C.; Hoxie, J.A.; March, Mark.

    In: Journal of Cell Biology, No. 139, no. 3, 1997, p. 651-664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Plagiarism of the host immune system - lessons about chemokine immunology from viruses. / Wells, T.N.C.; Schwartz, Thue W.

    In: Current Opinion in Biotechnology, No. 8, no. 6, 1997, p. 741-748.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 17.06.2008, p. 23121-23128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 2008, p. 23121-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 11601